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Two-phase systems developed with hydrophilic and hydrophobic deep eutectic solvents for simultaneously extracting various bioactive compounds with different polarities
Green Chemistry ( IF 9.3 ) Pub Date : 2018-03-20 , DOI: 10.1039/c7gc03820h Jun Cao 1, 2, 3, 4, 5 , Luyao Chen 1, 2, 3, 4 , Mohan Li 1, 2, 3, 4 , Fuliang Cao 2, 3, 4, 5, 6 , Linguo Zhao 2, 3, 4, 5, 6 , Erzheng Su 1, 2, 3, 4, 5
Green Chemistry ( IF 9.3 ) Pub Date : 2018-03-20 , DOI: 10.1039/c7gc03820h Jun Cao 1, 2, 3, 4, 5 , Luyao Chen 1, 2, 3, 4 , Mohan Li 1, 2, 3, 4 , Fuliang Cao 2, 3, 4, 5, 6 , Linguo Zhao 2, 3, 4, 5, 6 , Erzheng Su 1, 2, 3, 4, 5
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Two-phase systems developed with hydrophilic deep eutectic solvents (DESs) and hydrophobic DESs were prepared in this study for the first time. Ginkgo biloba leaves containing several bioactive compounds were chosen as the model plant material to evaluate the possibility of the two-phase DES system as a designer solvent for the simultaneous extraction of the various bioactive compounds with different polarities. After tailoring, a two-phase DES system prepared with two hydrophilic DESs and one hydrophobic DES at a volume ratio of 35 : 5 : 40 could effectively extract flavonoids, terpene trilactones (TTLs), procyanidine (PAC) and polyprenyl acetates (PPAs) simultaneously from the Ginkgo biloba leaves. The extraction conditions were further optimized using the response surface methodology. When the two-phase DES system was employed in the extraction under the optimal conditions, the PPAs moved into the hydrophobic phase, and the flavonoids, TTLs, and PAC were enriched into the hydrophilic phase. The first extraction rates for PAC, flavonoids, TTLs and PPAs were 86.07%, 77.72%, 93.29% and 94.63%, respectively. After extraction, the hydrophilic and hydrophobic phases containing different bioactive compounds could be easily separated for different preparations. Extraction with the two-phase DES system is a new application trial of DESs, which has the potential to be widely used for the extraction of bioactive compounds from plant materials or removal of different polar impurities from specific extracts.
中文翻译：
使用亲水性和疏水性深共熔溶剂开发的两相系统，用于同时提取具有不同极性的各种生物活性化合物
本研究首次制备了由亲水性深共熔溶剂（DES）和疏水性DES开发的两相系统。选择含有几种生物活性化合物的银杏叶作为模型植物材料，以评估两相DES系统作为设计溶剂同时提取具有不同极性的各种生物活性化合物的可能性。定制后，由两个亲水性DES和一个疏水性DES以35：5：40的体积比制备的两相DES系统可以有效地同时提取类黄酮，萜烯三内酯（TTL），原氰胺（PAC）和聚异戊二烯乙酸酯（PPA）从银杏叶树叶。使用响应面方法进一步优化了提取条件。当在最佳条件下采用两相DES系统萃取时，PPA进入疏水相，而类黄酮，TTL和PAC富集到亲水相中。PAC，类黄酮，TTL和PPA的首次提取率分别为86.07％，77.72％，93.29％和94.63％。提取后，可以轻松地将含有不同生物活性化合物的亲水相和疏水相分离出来，以用于不同的制剂。两相DES系统萃取是DES的一项新应用试验，它有可能被广泛用于从植物材料中萃取生物活性化合物或从特定萃取物中去除不同极性杂质的潜力。
更新日期：2018-04-23
中文翻译：
使用亲水性和疏水性深共熔溶剂开发的两相系统，用于同时提取具有不同极性的各种生物活性化合物
本研究首次制备了由亲水性深共熔溶剂（DES）和疏水性DES开发的两相系统。选择含有几种生物活性化合物的银杏叶作为模型植物材料，以评估两相DES系统作为设计溶剂同时提取具有不同极性的各种生物活性化合物的可能性。定制后，由两个亲水性DES和一个疏水性DES以35：5：40的体积比制备的两相DES系统可以有效地同时提取类黄酮，萜烯三内酯（TTL），原氰胺（PAC）和聚异戊二烯乙酸酯（PPA）从银杏叶树叶。使用响应面方法进一步优化了提取条件。当在最佳条件下采用两相DES系统萃取时，PPA进入疏水相，而类黄酮，TTL和PAC富集到亲水相中。PAC，类黄酮，TTL和PPA的首次提取率分别为86.07％，77.72％，93.29％和94.63％。提取后，可以轻松地将含有不同生物活性化合物的亲水相和疏水相分离出来，以用于不同的制剂。两相DES系统萃取是DES的一项新应用试验，它有可能被广泛用于从植物材料中萃取生物活性化合物或从特定萃取物中去除不同极性杂质的潜力。
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