Abstract The primary aim of this investigation was to improve the chiral separation performance of graphene oxide (GO) based composite membranes via tuning the interlayer spacing between GO sheets using the association of poly( L -Glutamic acid sodium), PLGA, onto the surface of GO sheets. Results show that: i) compared with conventional chiral separation membranes, these membranes exhibit superior chiral resolution properties, which are 1–2 orders of magnitude higher in the flux and greater in the enantioselectivity; ii) compared with pristine L-Glutamic modified GO membranes, they also afford a significant improvement in enantioselectivity with a slight reduction in flux. In present work, it is demonstrated that in such composite membranes, the incorporated PLGA can not only serve as an additional chiral recognizing agent, facilitating the transport of D-isomer of the chiral probe, but also as a kind of filler, reducing the size of pores or channels between GO sheets. Especially, both roles can significantly contribute to enhancing the enantioselectivitiy of composite membranes. Our findings indicate that the combination of GO-based materials and polypeptides might offer unusual control in the selectivity and the flux of the corresponding composite membranes, achieved by regulating the interlayer spacing between GO sheets, and thus such composite membranes have a potential to simultaneously facilitate high-flux and high-selectivity and a promising application in a great number of enantio- and bio-separations.

中文翻译：

---

填充的 PL GA 在提高 Glu-GO/PL GA 复合膜的对映选择性中的作用

摘要 本研究的主要目的是通过使用聚（L-谷氨酸钠）PLGA 的结合来调节 GO 片之间的层间距，从而提高基于氧化石墨烯（GO）的复合膜的手性分离性能。去表。结果表明：i）与传统的手性分离膜相比，这些膜表现出优异的手性分离特性，通量高1-2个数量级，对映选择性更大；ii) 与原始的 L-谷氨酸修饰的 GO 膜相比，它们还显着提高了对映选择性，但通量略有降低。在目前的工作中，证明在这种复合膜中，掺入的 PLGA 不仅可以作为额外的手性识别剂，促进手性探针的 D-异构体的运输，但也作为一种填料，减少 GO 片之间的孔或通道的大小。特别是，这两种作用都可以显着提高复合膜的对映选择性。我们的研究结果表明，基于 GO 的材料和多肽的组合可能通过调节 GO 片之间的层间距来实现对相应复合膜的选择性和通量的不同寻常的控制，因此这种复合膜有可能同时促进高通量和高选择性，在大量对映分离和生物分离中具有广阔的应用前景。这两种作用都可以显着提高复合膜的对映选择性。我们的研究结果表明，基于 GO 的材料和多肽的组合可能通过调节 GO 片之间的层间距来实现对相应复合膜的选择性和通量的异常控制，因此这种复合膜有可能同时促进高通量和高选择性，在大量对映分离和生物分离中具有广阔的应用前景。这两种作用都可以显着提高复合膜的对映选择性。我们的研究结果表明，基于 GO 的材料和多肽的组合可能通过调节 GO 片之间的层间距来实现对相应复合膜的选择性和通量的异常控制，因此这种复合膜有可能同时促进高通量和高选择性，在大量对映分离和生物分离中具有广阔的应用前景。