2,3,3,3-Tetrafluoro-2-(heptafluoropropoxy)propanoate (known as GenX) has been used as an alternative to perfluorooctanoic acid (PFOA) which was phased out of formulations for industrial and consumer product applications in 2015. While the effects of GenX on lab animals have been studied, little is known about its effects on plants. This study examined and compared the accumulation and toxicity of GenX and PFOA in the model plants Arabidopsis thaliana and Nicotiana benthamiana. Both plants showed reduction in biomass and root growth following exposure to PFOA or GenX in a dosage-dependent manner. The bioaccumulation factors (BFs) of GenX and PFOA were plant species-dependent, with higher BFs in A. thaliana compared to N. bethanminana. Additionally, GenX and PFOA were more readily accumulated into shoot tissues of A. thaliana than in N. bethanminana. Exposure to GenX also caused a reduction in chlorophyll content (18%) and total phenolic compounds (26%). However, GenX exposure increased superoxide dismutase activity and H₂O₂ content (1.6 and 2.6 folds increase, respectively) in N. benthamiana. Overall, our result suggest that GenX is bioaccumulative, and that its accumulation likely inhibits plant growth and photosynthesis as well as inducing oxidative stress.

2,3,3,3-四氟-2-（七氟丙氧基）丙酸酯（称为 GenX）已被用作全氟辛酸 (PFOA) 的替代品，全氟辛酸 (PFOA) 已于 2015 年逐步淘汰用于工业和消费品应用的配方。虽然已经研究了 GenX 对实验室动物的影响，但对其对植物的影响知之甚少。本研究检查并比较了 GenX 和 PFOA 在模式植物拟南芥和本氏烟草中的积累和毒性。两种植物在暴露于 PFOA 或 GenX 后均以剂量依赖性方式显示生物量和根系生长减少。GenX 和 PFOA 的生物积累因子 (BFs) 依赖于植物物种，与N. bethanminana相比，拟南芥中的生物积累因子 (BFs) 更高. 此外，与N. bethanminana相比，GenX和 PFOA 更容易积聚到拟南芥的枝条组织中。暴露于 GenX 还导致叶绿素含量 (18%) 和总酚类化合物 (26%) 减少。然而，GenX 暴露增加了本氏烟草中的超氧化物歧化酶活性和 H ₂ O ₂含量（分别增加了 1.6 和 2.6 倍）。总的来说，我们的结果表明 GenX 是生物累积性的，它的累积可能会抑制植物生长和光合作用以及诱导氧化应激。