2,3,3,3-Tetrafluoro-2-(heptafluoropropoxy)propanoate (known as GenX) has been used as an alternative to perfluorooctanoic acid (PFOA) which was phased out of formulations for industrial and consumer product applications in 2015. While the effects of GenX on lab animals have been studied, little is known about its effects on plants. This study examined and compared the accumulation and toxicity of GenX and PFOA in the model plants Arabidopsis thaliana and Nicotiana benthamiana. Both plants showed reduction in biomass and root growth following exposure to PFOA or GenX in a dosage-dependent manner. The bioaccumulation factors (BFs) of GenX and PFOA were plant species-dependent, with higher BFs in A. thaliana compared to N. bethanminana. Additionally, GenX and PFOA were more readily accumulated into shoot tissues of A. thaliana than in N. bethanminana. Exposure to GenX also caused a reduction in chlorophyll content (18%) and total phenolic compounds (26%). However, GenX exposure increased superoxide dismutase activity and H₂O₂ content (1.6 and 2.6 folds increase, respectively) in N. benthamiana. Overall, our result suggest that GenX is bioaccumulative, and that its accumulation likely inhibits plant growth and photosynthesis as well as inducing oxidative stress.

2,3,3,3-四氟-2-(七氟丙氧基)丙酸酯（称为 GenX）已被用作全氟辛酸 (PFOA) 的替代品，全氟辛酸 (PFOA) 已于 2015 年从工业和消费品应用配方中逐步淘汰。 GenX 对实验室动物的影响已被研究，但对其对植物的影响知之甚少。本研究检测并比较了模式植物拟南芥和本塞姆氏烟草中 GenX 和 PFOA 的积累和毒性。两种植物在接触 PFOA 或 GenX 后均表现出生物量和根部生长的减少，且呈剂量依赖性。 GenX 和 PFOA 的生物累积因子 (BF) 取决于植物种类，与N. bethanminana相比，拟南芥的BF 更高。此外，GenX 和 PFOA 比N. bethanminana更容易积累到拟南芥的芽组织中。接触 GenX 还会导致叶绿素含量 (18%) 和总酚化合物 (26%) 减少。然而，GenX暴露增加了本塞姆氏烟草中的超氧化物歧化酶活性和H ₂ O ₂含量（分别增加1.6倍和2.6倍）。总体而言，我们的结果表明 GenX 具有生物累积性，其累积可能会抑制植物生长和光合作用并诱导氧化应激。