Progress and challenges in engineering cyanobacteria as chassis for light-driven biotechnology.,Microbial Biotechnology

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Progress and challenges in engineering cyanobacteria as chassis for light-driven biotechnology.
Microbial Biotechnology ( IF 4.8 ) Pub Date : 2019-12-27 , DOI: 10.1111/1751-7915.13526
Andrew Hitchcock ₁ , C Neil Hunter ₁ , Daniel P Canniffe ₂

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Cyanobacteria are prokaryotic phototrophs that, in addition to being excellent model organisms for studying photosynthesis, have tremendous potential for light‐driven synthetic biology and biotechnology. These versatile and resilient microorganisms harness the energy of sunlight to oxidise water, generating chemical energy (ATP) and reductant (NADPH) that can be used to drive sustainable synthesis of high‐value natural products in genetically modified strains. In this commentary article for the Synthetic Microbiology Caucus we discuss the great progress that has been made in engineering cyanobacterial hosts as microbial cell factories for solar‐powered biosynthesis. We focus on some of the main areas where the synthetic biology and metabolic engineering tools in cyanobacteria are not as advanced as those in more widely used heterotrophic chassis, and go on to highlight key improvements that we feel are required to unlock the full power of cyanobacteria for future green biotechnology.

中文翻译：

工程蓝细菌作为光驱动生物技术的底盘的进展和挑战。

蓝细菌是原核生物的光养菌，除了是研究光合作用的优秀模式生物外，在光驱动合成生物学和生物技术方面也具有巨大潜力。这些多用途且具有复原力的微生物利用阳光的能量来氧化水，产生化学能（ATP）和还原剂（NADPH），可用于驱动转基因菌株中高价值天然产物的可持续合成。在这篇有关“合成微生物学核心小组”的评论文章中，我们讨论了工程化蓝细菌宿主作为太阳能生物合成的微生物细胞工厂所取得的巨大进步。我们专注于某些主要领域，在这些领域中，蓝细菌的合成生物学和代谢工程工具不如在更广泛使用的异养底盘中先进，

更新日期：2019-12-27

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