具有双重对比的多种 MRI 造影剂的动态、同步浓度映射 - 磁共振指纹图谱。,Scientific Reports

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具有双重对比的多种 MRI 造影剂的动态、同步浓度映射 - 磁共振指纹图谱。
Scientific Reports ( IF 3.8 ) Pub Date : 2019-12-27 , DOI: 10.1038/s41598-019-56531-7
Christian E Anderson _{1,

2} , Mette Johansen ₃ , Bernadette O Erokwu ₁ , He Hu _{2,

4} , Yuning Gu ₂ , Yifan Zhang ₁ , Michael Kavran ₁ , Jason Vincent ₃ , Mitchell L Drumm _{5,

6} , Mark A Griswold _{1,

2} , Nicole F Steinmetz _{1,

2,

4,

7,

8} , Ming Li ₉ , Heather Clark _{10,

11,

12} , Rebecca J Darrah _{5,

13} , Xin Yu _{2,

14} , Susann M Brady-Kalnay _{3,

15} , Chris A Flask _{1,

2,

6}

Affiliation

Department of Radiology, Case Western Reserve University, Cleveland, OH, USA.
Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA.
Department of Molecular Biology and Microbiology, Case Western Reserve University, Cleveland, OH, USA.
Department of NanoEngineering, University of California-San Diego, La Jolla, CA, USA.
Department of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, OH, USA.
Department of Pediatrics, Case Western Reserve University, Cleveland, OH, USA.
Department of Radiology, University of California-San Diego, La Jolla, CA, USA.
Moores Cancer Center, University of California-San Diego, La Jolla, CA, USA.
Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA.
Department of Bioengineering, Northeastern University, Boston, MA, USA.
Department of Chemistry and Chemical Biology, Northeastern University, Boston, MA, USA.
Institute of Systems Bioanalysis and Chemical Imaging, Northeastern University, Boston, MA, USA.
Francis Payne Bolton School of Nursing, Case Western Reserve University, Cleveland, OH, USA.
Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, OH, USA.
Department of Neurosciences, Case Western Reserve University, Cleveland, OH, USA.

在单次扫描过程中同步评估多种 MRI 造影剂将提供类似于荧光成像的新“多色”成像功能，但具有高时空分辨率和无限的成像深度。这种多代理 MRI 技术将使全新的基础科学和临床 MRI 实验成为可能，同时探索体内的多个生理/分子事件。不幸的是，传统的 MRI 采集技术一次只能检测和量化一种顺磁 MRI 造影剂。在此，双对比 - 磁共振指纹 (DC-MRF) 方法扩展到体内应用，并通过同时动态绘制两种 MRI 对比剂（Gd-BOPTA 和 Dy-DOTA-叠氮化物）的肿瘤内浓度进行评估。小鼠神经胶质瘤模型。共同配准的钆和镝浓度图以亚毫米空间分辨率生成，并以超过 2 分钟的时间分辨率动态获取。单剂和双剂 DC-MRF 研究的平均肿瘤 Gd 和 Dy 浓度测量结果表明与离体质谱元素分析显着相关。这项初步的体内研究证明了 DC-MRF 提供有用的双代理 MRI 平台的潜力。

"点击查看英文标题和摘要"

Dynamic, Simultaneous Concentration Mapping of Multiple MRI Contrast Agents with Dual Contrast - Magnetic Resonance Fingerprinting.

Synchronous assessment of multiple MRI contrast agents in a single scanning session would provide a new "multi-color" imaging capability similar to fluorescence imaging but with high spatiotemporal resolution and unlimited imaging depth. This multi-agent MRI technology would enable a whole new class of basic science and clinical MRI experiments that simultaneously explore multiple physiologic/molecular events in vivo. Unfortunately, conventional MRI acquisition techniques are only capable of detecting and quantifying one paramagnetic MRI contrast agent at a time. Herein, the Dual Contrast - Magnetic Resonance Fingerprinting (DC-MRF) methodology was extended for in vivo application and evaluated by simultaneously and dynamically mapping the intra-tumoral concentration of two MRI contrast agents (Gd-BOPTA and Dy-DOTA-azide) in a mouse glioma model. Co-registered gadolinium and dysprosium concentration maps were generated with sub-millimeter spatial resolution and acquired dynamically with just over 2-minute temporal resolution. Mean tumor Gd and Dy concentration measurements from both single agent and dual agent DC-MRF studies demonstrated significant correlations with ex vivo mass spectrometry elemental analyses. This initial in vivo study demonstrates the potential for DC-MRF to provide a useful dual-agent MRI platform.

更新日期：2019-12-27

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