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Intravoxel Incoherent Motion Magnetic Resonance Imaging with Integrated Slice-specific Shimming for old myocardial infarction: A Pilot Study.
Scientific Reports ( IF 3.8 ) Pub Date : 2019-12-24 , DOI: 10.1038/s41598-019-56489-6 Shi-Feng Xiang 1 , Xue-Qiang Zhang 1 , Su-Jun Yang 1 , Yun-Yun Gao 1 , Bu-Lang Gao 1 , Qing-Lei Shi 2 , Shuai Li 2
Scientific Reports ( IF 3.8 ) Pub Date : 2019-12-24 , DOI: 10.1038/s41598-019-56489-6 Shi-Feng Xiang 1 , Xue-Qiang Zhang 1 , Su-Jun Yang 1 , Yun-Yun Gao 1 , Bu-Lang Gao 1 , Qing-Lei Shi 2 , Shuai Li 2
Affiliation
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Currently, little is known regarding the value of quantitative parameters derived from the intravoxel incoherent motion (IVIM) magnetic resonance imaging (MRI) with integrated slice-specific shimming (iShim) sequence in detecting old myocardial infarction and myocardial fibrosis. This study was to investigate the value of IVIM-MRI with iShim sequence in diagnosing old myocardial infarction and fibrosis. Thirty-five patients with both old myocardial infarction and myocardial fibrosis and 12 healthy volunteers were prospectively enrolled to undergo cardiac diffusion-weighted imaging (DWI) using seven b-values (0, 20, 60, 80, 120, 200 and 600 s/mm2). The iShim sequence was used for IVIM data acquisition, and the diffusion parameters, D, D* and f values for IVIM, and conventional apparent diffusion coefficient (ADC) were evaluated on the anterior, posterior and lateral walls of the ventricular septum using the short axis of the heart. Significant differences were found in the D, D* and f values between healthy subjects and patients with old myocardial infarction and myocardial fibrosis (P = 0.000), with the median value of the D and f significantly smaller in the myocardial infarction and fibrosis than in the normal control but the median value of D* significantly greater in the myocardial infarction and fibrosis than in the normal control. In the receiver operating curve analysis, the areas under the curve were 0.939, 0.988 and 0.959 for the D, D* and f values, respectively. The sensitivities and specificities were 84.6% and 94.4% for D, 88.9% and 84.6% for D* and 100% and 93.1% for the f values, respectively. In conclusion, the IVIM-derived parameters (D, D* and f) obtained using the iShim DWI technique showed high capacity in diagnosing old myocardial infarction and myocardial fibrosis by providing diffusion and perfusion information, which may have great importance in future clinical practice.
中文翻译：
集成切片特异性匀场的Invovoxel不相干运动磁共振成像对老年心肌梗塞的一项先导研究。
目前，关于体内超声不相干运动（IVIM）磁共振成像（MRI）和整合的切片特异性匀场（iShim）序列的定量参数在检测老年心肌梗塞和心肌纤维化中的价值知之甚少。本研究旨在探讨具有iShim序列的IVIM-MRI在诊断老年心肌梗塞和纤维化中的价值。前瞻性招募了35例既有心肌梗塞又有心肌纤维化的患者和12名健康志愿者，使用7个b值（0、20、60、80、120、200和600 s /平方毫米）。使用iShim序列进行IVIM数据采集，并在前侧评估扩散参数，IVIM的扩散参数，D，D *和f值以及常规的表观扩散系数（ADC），室间隔的后壁和侧壁使用心脏的短轴。在健康受试者与患有老年心肌梗塞和心肌纤维化的患者之间，D，D *和f值存在显着差异（P = 0.000），在心肌梗塞和纤维化中，D和f的中值显着小于对照组。与正常对照组相比，D *的中位数在心肌梗塞和纤维化中明显高于正常对照组。在接收器工作曲线分析中，曲线下的D，D *和f值分别为0.939、0.988和0.959。D的敏感性和特异性分别为84.6％和94.4％，D *的敏感性和特异性分别为88.9％和84.6％，f值分别为100％和93.1％。总之，IVIM衍生的参数（D，
更新日期：2019-12-25
中文翻译：
集成切片特异性匀场的Invovoxel不相干运动磁共振成像对老年心肌梗塞的一项先导研究。
目前，关于体内超声不相干运动（IVIM）磁共振成像（MRI）和整合的切片特异性匀场（iShim）序列的定量参数在检测老年心肌梗塞和心肌纤维化中的价值知之甚少。本研究旨在探讨具有iShim序列的IVIM-MRI在诊断老年心肌梗塞和纤维化中的价值。前瞻性招募了35例既有心肌梗塞又有心肌纤维化的患者和12名健康志愿者，使用7个b值（0、20、60、80、120、200和600 s /平方毫米）。使用iShim序列进行IVIM数据采集，并在前侧评估扩散参数，IVIM的扩散参数，D，D *和f值以及常规的表观扩散系数（ADC），室间隔的后壁和侧壁使用心脏的短轴。在健康受试者与患有老年心肌梗塞和心肌纤维化的患者之间，D，D *和f值存在显着差异（P = 0.000），在心肌梗塞和纤维化中，D和f的中值显着小于对照组。与正常对照组相比，D *的中位数在心肌梗塞和纤维化中明显高于正常对照组。在接收器工作曲线分析中，曲线下的D，D *和f值分别为0.939、0.988和0.959。D的敏感性和特异性分别为84.6％和94.4％，D *的敏感性和特异性分别为88.9％和84.6％，f值分别为100％和93.1％。总之，IVIM衍生的参数（D，
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