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Flavin-containing monooxygenases: new structures from old proteins.
Nature Structural & Molecular Biology ( IF 12.5 ) Pub Date : 2019-12-23 , DOI: 10.1038/s41594-019-0356-1
Ian R Phillips 1, 2 , Elizabeth A Shephard 1
Affiliation  

A study reports the structures of membrane-bound flavin-containing monooxygenases (FMOs), solved using reconstructed ancestral mammalian FMOs. The models provide a structural basis for these enzymes’ mechanism of action and show how the proteins interact with membranes and how substrates access their active sites.

中文翻译:

含黄素的单加氧酶:来自旧蛋白质的新结构。

一项研究报告了使用重建的祖先哺乳动物FMO解决的膜结合的含黄素单加氧酶(FMO)的结构。这些模型为这些酶的作用机理提供了结构基础,并显示了蛋白质如何与膜相互作用以及底物如何进入其活性位点。
更新日期:2019-12-23
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