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Fabrication of CS/SA Double‐Network Hydrogel and Application in pH‐Controllable Drug Release
ChemistrySelect ( IF 1.9 ) Pub Date : 2019-12-20 , DOI: 10.1002/slct.201904325
Yuanze Li 1 , Haili Wang 1 , Yuzhong Niu 1 , Songmei Ma 1 , Zhongxin Xue 1 , Aixin Song 2 , Shaohua Zhang 1 , Wenlong Xu 1 , Chunguang Ren 3
ChemistrySelect ( IF 1.9 ) Pub Date : 2019-12-20 , DOI: 10.1002/slct.201904325
Yuanze Li 1 , Haili Wang 1 , Yuzhong Niu 1 , Songmei Ma 1 , Zhongxin Xue 1 , Aixin Song 2 , Shaohua Zhang 1 , Wenlong Xu 1 , Chunguang Ren 3
Affiliation
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In order to promote the application range, double‐network hydrogels are usually fabricated to improve the mechanical properties. In this work, chitosan (CS) single‐network hydrogels were prepared firstly and sodium alginate (SA) was introduced as the second network. According to scanning electron microscopy (SEM), the microstructures of the CS and SA single‐network were identified as three‐dimensional network of pore and fiber structure, respectively. The microstructure maintained the pore structure after the formation of CS/SA double‐network due to the small amount of SA. The size of the pores was reduced, indicating the cross‐linking of the double‐network. The rheological results indicated that CS/SA double‐network with small amount of SA could enhance the mechanical strength of the hydrogel effectively. Finally, the in vitro release was operated, verifying the sustained release ability of the double‐network hydrogel. In addition, only small amount of the drug could be release in physiological environment (pH 7.4), while a quickly release was obtained in pathological tissue (pH 5.5), decreasing the side effect of the drug.
中文翻译：
CS / SA双网络水凝胶的制备及其在pH可控药物释放中的应用
为了扩大应用范围，通常制造双网状水凝胶以改善机械性能。在这项工作中，首先制备了壳聚糖（CS）单网络水凝胶，然后引入了海藻酸钠（SA）作为第二网络。根据扫描电子显微镜（SEM），CS和SA单网络的微观结构分别被识别为孔结构和纤维结构的三维网络。由于少量的SA，在CS / SA双网形成后，微观结构保持了孔结构。孔的尺寸减小，表明双网络的交联。流变学结果表明，少量SA的CS / SA双网可有效提高水凝胶的机械强度。最后，操作了体外释放，验证了双网络水凝胶的持续释放能力。此外，在生理环境（pH 7.4）中只能释放少量药物，而在病理组织（pH 5.5）中可以快速释放药物，从而降低了药物的副作用。
更新日期：2019-12-20
中文翻译：
CS / SA双网络水凝胶的制备及其在pH可控药物释放中的应用
为了扩大应用范围，通常制造双网状水凝胶以改善机械性能。在这项工作中，首先制备了壳聚糖（CS）单网络水凝胶，然后引入了海藻酸钠（SA）作为第二网络。根据扫描电子显微镜（SEM），CS和SA单网络的微观结构分别被识别为孔结构和纤维结构的三维网络。由于少量的SA，在CS / SA双网形成后，微观结构保持了孔结构。孔的尺寸减小，表明双网络的交联。流变学结果表明，少量SA的CS / SA双网可有效提高水凝胶的机械强度。最后，操作了体外释放，验证了双网络水凝胶的持续释放能力。此外，在生理环境（pH 7.4）中只能释放少量药物，而在病理组织（pH 5.5）中可以快速释放药物，从而降低了药物的副作用。
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