The skin is the outermost barrier of the organism that ensures protection from external harm. Lately, our view of the skin has evolved from an inert mechanical barrier to an active organ that can sense danger signals and mount perfectly adapted defense measures in response to invading pathogens. This Review highlights the different levels of the cutaneous barrier (the microbiome, chemical, physical, and immune barriers), their characteristics, and functional, highly interconnected network of cells and mediators that allow balanced defense measures to protect the body and maintain barrier integrity.

中文翻译：

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皮肤屏障和皮肤免疫力：区分连接的网络

皮肤是生物体的最外层屏障，可确保免受外部伤害。最近，我们对皮肤的看法已从惰性的机械屏障演变为可以感知危险信号并针对入侵的病原体采取完全适应的防御措施的活动器官。这篇综述重点介绍了皮肤屏障的不同水平（微生物组，化学，物理和免疫屏障），它们的特征以及功能性，高度相互联系的细胞和介体网络，这些网络可以采取平衡的防御措施来保护人体并维持屏障的完整性。