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Coadministration of an Adhesive Conductive Hydrogel Patch and an Injectable Hydrogel to Treat Myocardial Infarction.
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2019-12-20 , DOI: 10.1021/acsami.9b17907 Tengling Wu 1 , Chunyan Cui 1 , Yuting Huang 2 , Yang Liu 1 , Chuanchuan Fan 1 , Xiaoxu Han 1 , Yang Yang 1 , Ziyang Xu 1 , Bo Liu 1 , Guanwei Fan 2 , Wenguang Liu 1
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2019-12-20 , DOI: 10.1021/acsami.9b17907 Tengling Wu 1 , Chunyan Cui 1 , Yuting Huang 2 , Yang Liu 1 , Chuanchuan Fan 1 , Xiaoxu Han 1 , Yang Yang 1 , Ziyang Xu 1 , Bo Liu 1 , Guanwei Fan 2 , Wenguang Liu 1
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Over the past decade, tissue-engineering strategies, mainly involving injectable hydrogels and epicardial biomaterial patches, have been pursued to treat myocardial infarction. However, only limited therapeutic efficacy is achieved with a single means. Here, a combined therapy approach is proposed, that is, the coadministration of a conductive hydrogel patch and injectable hydrogel to the infarcted myocardium. The self-adhesive conductive hydrogel patch is fabricated based on Fe3+-induced ionic coordination between dopamine-gelatin (GelDA) conjugates and dopamine-functionalized polypyrrole (DA-PPy), which form a homogeneous network. The injectable and cleavable hydrogel is formed in situ via a Schiff base reaction between oxidized sodium hyaluronic acid (HA-CHO) and hydrazided hyaluronic acid (HHA). Compared with a single-mode system, injecting the HA-CHO/HHA hydrogel intramyocardially followed by painting a conductive GelDA/DA-PPy hydrogel patch on the heart surface results in a more pronounced improvement of the cardiac function in terms of echocardiographical, histological, and angiogenic outcomes.
中文翻译：
胶粘剂导电水凝胶贴剂和可注射水凝胶的共同给药可治疗心肌梗塞。
在过去的十年中，已经采取了组织工程策略，主要涉及可注射的水凝胶和心外膜生物材料贴剂，以治疗心肌梗塞。但是，仅用一种方法就只能达到有限的治疗效果。在此，提出了一种联合治疗方法，即，将导电性水凝胶贴剂和可注射水凝胶共同施用至梗塞的心肌。基于Fe3 +诱导的多巴胺-明胶（GelDA）共轭物与多巴胺官能化的聚吡咯（DA-PPy）之间的离子配位，制得了自粘导电水凝胶贴剂，形成了均匀的网络。通过氧化的透明质酸钠（HA-CHO）和酰化的透明质酸（HHA）之间的席夫碱反应原位形成可注射和可裂解的水凝胶。与单模系统相比，
更新日期：2020-01-04
中文翻译：
胶粘剂导电水凝胶贴剂和可注射水凝胶的共同给药可治疗心肌梗塞。
在过去的十年中，已经采取了组织工程策略，主要涉及可注射的水凝胶和心外膜生物材料贴剂，以治疗心肌梗塞。但是，仅用一种方法就只能达到有限的治疗效果。在此，提出了一种联合治疗方法，即，将导电性水凝胶贴剂和可注射水凝胶共同施用至梗塞的心肌。基于Fe3 +诱导的多巴胺-明胶（GelDA）共轭物与多巴胺官能化的聚吡咯（DA-PPy）之间的离子配位，制得了自粘导电水凝胶贴剂，形成了均匀的网络。通过氧化的透明质酸钠（HA-CHO）和酰化的透明质酸（HHA）之间的席夫碱反应原位形成可注射和可裂解的水凝胶。与单模系统相比，
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