Benzene-1,3,5-triyl Triformate (TFBen)-Promoted Palladium-Catalyzed Carbonylative Synthesis of 2-Oxo-2,5-dihydropyrroles from Propargyl Amines.,Organic Letters

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Benzene-1,3,5-triyl Triformate (TFBen)-Promoted Palladium-Catalyzed Carbonylative Synthesis of 2-Oxo-2,5-dihydropyrroles from Propargyl Amines.
Organic Letters ( IF 4.9 ) Pub Date : 2019-12-20 , DOI: 10.1021/acs.orglett.9b04147
Jun Ying _{1,

2} , Zhengjie Le ₁ , Xiao-Feng Wu _{1,

3}

Affiliation

In this letter, we developed a palladium-catalyzed procedure for the cyclocarbonylation of propargyl amines. Benzene-1,3,5-triyl triformate (TFBen) has been explored as the CO source and also as the key promotor. Various substituted 2-oxo-dihydropyrroles were produced in a facile manner in good yields (up to 90%).

中文翻译：

1,2,3,5-三甲酸三甲苯酯（TFBen）促进的钯催化的炔丙基胺合成2-Oxo-2,5-二氢吡咯的羰基化反应。

在这封信中，我们开发了钯催化的炔丙基胺环羰基化的方法。苯甲酸1,3,5-三甲酸三乙酯（TFBen）已被研究用作CO的来源，也是主要的促进剂。以容易的方式以良好的产率（高达90％）生产了各种取代的2-氧代-二氢吡咯。

更新日期：2019-12-20

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