Reductive amidation of alkyl tosylates with isocyanates by a Ni/Co-dual catalytic system.,Chemical Communications

当前位置： X-MOL 学术 › Chem. Commun. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Reductive amidation of alkyl tosylates with isocyanates by a Ni/Co-dual catalytic system.
Chemical Communications ( IF 4.3 ) Pub Date : 2020-01-03 , DOI: 10.1039/c9cc09377j
Takuya Michiyuki ₁ , Itaru Osaka , Kimihiro Komeyama

Affiliation

Reductive amidation of alkyl tosylates with isocyanates using the Ni/Co-dual catalytic system is disclosed. The method proceeds efficiently under mild conditions, giving rise to the corresponding alkyl amides. Notably, the protocol can discriminate the steric environment of two alkyl tosylate moieties, enabling regioselective mono-amidation at the less-bulky site.

中文翻译：

Ni / Co-双重催化体系将甲苯磺酸烷基酯与异氰酸酯还原酰胺化。

公开了使用Ni / Co-双催化体系对甲苯磺酸烷基酯与异氰酸酯的还原酰胺化。该方法在温和条件下有效地进行，得到相应的烷基酰胺。值得注意的是，该协议可以区分两个甲苯磺酸烷基酯部分的空间环境，从而在较小的位点实现区域选择性单酰胺化。

更新日期：2020-01-04

点击分享查看原文

点击收藏

阅读更多本刊新发论文本刊介绍/投稿指南