Maternal smoking, genetic susceptibility, and birth-to-adulthood body weight.,International Journal of Obesity

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Maternal smoking, genetic susceptibility, and birth-to-adulthood body weight.
International Journal of Obesity ( IF 4.2 ) Pub Date : 2019-12-19 , DOI: 10.1038/s41366-019-0509-7
Dianjianyi Sun ₁ , Tao Zhou ₂ , Xiang Li ₂ , Sylvia H Ley _{2,

3,

4} , Yoriko Heianza ₂ , Lu Qi _{2,

3,

4}

Affiliation

BACKGROUND Maternal smoking (MS) is associated with low birthweight (BW) but adult obesity in offspring, however, it remains unknown whether it modifies offspring's genetic susceptibility to obesity on BW, adult body weight, and birth-to-adulthood body weight tracking pattern. METHODS This study included 246,759 UK Biobank participants with information on MS, BW (kg), adult body weight and BMI (kg/m2). Individual polygenetic score (PGS) was created on the basis of 97 BMI-associated genetic loci. We calculated individual birth-to-adulthood percentile change, and body weight tracking patterns that combined BW levels (<2.5, 2.5-4.0, and ≥4.0 as low, normal and high BW [LBW, NBW, and HBW]) and adulthood obesity status (≥30 as obesity [OB] and <30 as non-obesity [NOB]), including LBW-to-OB, LBW-to-NOB, NBW-to-OB, NBW-to-NOB, HBW-to-OB, and HBW-to-NOB. RESULTS Participants exposed to MS had a 0.108 kg lower BW (95% CI, -0.114 to -0.102), a 1.418 kg higher adult body weight (95% CI, 1.291-1.545), and a 6.91 greater percentile increase of body weight from birth to adulthood (95% CI, 6.62-7.21), compared with those nonexposed (all P < 0.001). In comparison to participants of NBW-to-NOB, MS was associated with an approximately twofold higher risk of LBW-to-OB (odds ratio [OR] 1.98, 95% CI 1.87-2.10), and a reduced likelihood of HBW-to-NOB (0.85, 95% CI 0.82-0.88). The increases in BW, adult body weight, and birth-to-adulthood percentile change per increment of 10 BMI-PGS were 0.021 vs. 0.012, 2.50 vs. 2.11, and 4.03 vs. 3.55, respectively, for participants exposed vs. nonexposed to MS (all Pinteraction < 0.05). CONCLUSION Our results indicate that exposure to MS is associated with an increased risk of transition from low BW-to-adulthood obesity, and reduced likelihood of change from high BW-to-normal adult body weight. MS may modify the relation of genetic susceptibility to obesity and body weight in offspring.

中文翻译：

母亲吸烟、遗传易感性和出生至成年体重。

背景母亲吸烟 (MS) 与低出生体重 (BW) 相关，但后代成年后肥胖，然而，它是否会改变后代对体重、成年体重和出生至成年体重追踪模式的肥胖遗传易感性尚不清楚. 方法本研究包括 246,759 名英国生物样本库参与者，他们提供有关 MS、BW (kg)、成人体重和 BMI (kg/m2) 的信息。个体多基因评分 (PGS) 是在 97 个 BMI 相关基因位点的基础上创建的。我们计算了个体从出生到成年的百分位数变化，以及结合 BW 水平（<2.5、2.5-4.0 和 ≥4.0 为低、正常和高 BW [LBW、NBW 和 HBW]）和成年期肥胖的体重跟踪模式状态（≥30 为肥胖 [OB]，<30 为非肥胖 [NOB]），包括 LBW-to-OB、LBW-to-NOB、NBW-to-OB、NBW-to-NOB、HBW-to-产科，和 HBW 到 NOB。结果暴露于 MS 的参与者体重降低了 0.108 公斤（95% CI，-0.114 至 -0.102），成年体重增加了 1.418 公斤（95% CI，1.291-1.545），体重增加了 6.91 个百分点出生至成年 (95% CI, 6.62-7.21)，与未暴露者相比（所有 P < 0.001）。与 NBW-to-NOB 的参与者相比，MS 与 LBW-to-OB 的风险高出大约两倍（比值比 [OR] 1.98，95% CI 1.87-2.10），并且 HBW-to 的可能性降低-NOB（0.85，95% CI 0.82-0.88）。对于暴露于与未暴露于MS（所有 Pinteraction < 0.05）。结论我们的结果表明，暴露于 MS 与从低 BW 过渡到成年期肥胖的风险增加相关，并且与从高 BW 到正常成人体重变化的可能性降低相关。MS 可能会改变遗传易感性与后代肥胖和体重的关系。

更新日期：2019-12-19

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