A highly sensitive and selective fluorescent probe for fast sensing of endogenous HClO in living cells†,Chemical Communications

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A highly sensitive and selective fluorescent probe for fast sensing of endogenous HClO in living cells†
Chemical Communications ( IF 4.3 ) Pub Date : 2018-03-15 00:00:00 , DOI: 10.1039/c8cc01917g
Changyu Zhang _{1,

2,

3,

4} , Qichang Nie _{4,

5,

6,

7} , Ismail Ismail _{4,

6,

8,

9,

10} , Zhen Xi _{4,

6,

8,

9,

10} , Long Yi _{1,

2,

3,

4}

Affiliation

A new fluorescence probe was developed for HClO detection under physiological conditions, which displayed fast response (t_1/2 < 30 s) and large off–on fluorescence increase (>1000-fold) toward HClO with high sensitivity and selectivity. The probe was successfully applied for the detection of both exogenous and endogenous HClO in living cells. Using the probe-based tool, we could observe the H₂S-induced HClO biogenesis in living cells for the first time.

中文翻译：

用于快速检测活细胞中内源HClO的高灵敏度和选择性荧光探针†

已开发出一种用于在生理条件下检测HClO的新型荧光探针，该探针显示出对HClO的快速响应（t _1/2 <30 s）和较大的关闭-开启荧光（> 1000倍），具有高灵敏度和选择性。该探针已成功应用于活细胞中外源和内源HClO的检测。使用基于探针的工具，我们可以首次观察到H ₂ S诱导的活细胞中HClO生物发生。

更新日期：2018-03-15

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