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Synthesis of 1,2-amino alcohols by decarboxylative coupling of amino acid derived α-amino radicals to carbonyl compounds via visible-light photocatalyst in water
Green Chemistry ( IF 9.3 ) Pub Date : 2019/12/17 , DOI: 10.1039/c9gc03470f
Shulei Pan 1, 2, 3, 4, 5 , Min Jiang 1, 2, 3, 4, 5 , Jinjin Hu 1, 2, 3, 4, 5 , Ruigang Xu 1, 2, 3, 4, 5 , Xiaofei Zeng 1, 2, 3, 4, 5 , Guofu Zhong 1, 2, 3, 4, 5
Green Chemistry ( IF 9.3 ) Pub Date : 2019/12/17 , DOI: 10.1039/c9gc03470f
Shulei Pan 1, 2, 3, 4, 5 , Min Jiang 1, 2, 3, 4, 5 , Jinjin Hu 1, 2, 3, 4, 5 , Ruigang Xu 1, 2, 3, 4, 5 , Xiaofei Zeng 1, 2, 3, 4, 5 , Guofu Zhong 1, 2, 3, 4, 5
Affiliation
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A general and efficient visible-light photoredox-catalysed decarboxylative radical coupling reaction of N-aryl amino acids with aldehydes or ketones for the synthesis of various 1,2-amino alcohols by using water as the solvent at room temperature is described. This protocol is characterised by broad substrate scopes, mild reaction conditions and amenability to gram-scale synthesis, which opens up a simple, mild but effective method to produce 1,2-amino alcohols from readily available starting materials.
中文翻译:
通过可见光光催化剂在水中将氨基酸衍生的α-氨基自由基与羰基化合物进行脱羧偶联合成1,2-氨基醇
描述了在室温下用水作为溶剂,N-芳基氨基酸与醛或酮的通用且有效的可见光光氧化还原催化的脱羧自由基偶联反应,用于合成各种1,2-氨基醇。该方案的特点是具有广泛的底物范围,温和的反应条件和对克级合成的适应性,这为从容易获得的起始原料生产1,2-氨基醇提供了一种简单,温和但有效的方法。
更新日期:2020-02-10
中文翻译:
![](https://scdn.x-mol.com/jcss/images/paperTranslation.png)
通过可见光光催化剂在水中将氨基酸衍生的α-氨基自由基与羰基化合物进行脱羧偶联合成1,2-氨基醇
描述了在室温下用水作为溶剂,N-芳基氨基酸与醛或酮的通用且有效的可见光光氧化还原催化的脱羧自由基偶联反应,用于合成各种1,2-氨基醇。该方案的特点是具有广泛的底物范围,温和的反应条件和对克级合成的适应性,这为从容易获得的起始原料生产1,2-氨基醇提供了一种简单,温和但有效的方法。