Overview of recent developments of pyrazole derivatives as an anticancer agent in different cell line.,Bioorganic Chemistry

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Overview of recent developments of pyrazole derivatives as an anticancer agent in different cell line.
Bioorganic Chemistry ( IF 4.5 ) Pub Date : 2019-12-14 , DOI: 10.1016/j.bioorg.2019.103470
Fatima Ezzahra Bennani ₁ , Latifa Doudach ₂ , Yahia Cherrah ₃ , Youssef Ramli ₄ , Khalid Karrouchi ₄ , M'hammed Ansar ₄ , My El Abbes Faouzi ₃

Affiliation

Pyrazole is a five-membered aromatic heterocyclic ring with two adjacent nitrogen atoms C3H3N2H.The presence of this nucleus in pharmacological agents of various therapeutic categories gifts a broad spectrum of biological activities and pharmaceuticals that contain pyrazole like celecoxib (anti-inflammatory), CDPPB (antipsychotic), Rimonabant (anti-obesity), Difenamizole, (Analgesic), Betazole (H2 receptor agonist), Fezolamide (Antidepressant), etc… The pharmacological potential of the pyrazole fraction is proved in many publication where they synthesized and evaluated pyrazoles against several biological agents. The aim of this article review is to survey recent works linking pyrazole structures to anticancer activities corresponding to 9 different type of cancer.

中文翻译：

吡唑衍生物在不同细胞系中作为抗癌剂的最新进展概述。

吡唑是具有两个相邻氮原子C3H3N2H的五元芳族杂环，该核存在于各种治疗药物中，具有广泛的生物活性，并且含有吡唑类药物（如塞来昔布（消炎药），CDPPB（抗精神病药），利莫那班（抗肥胖药），地芬那唑（镇痛药），苯达唑（H2受体激动剂），非唑胺（抗抑郁药）等…吡唑部分的药理潜力在许多出版物中得到了证明，他们合成并评估了吡唑类药物对几种药物的作用。生物制剂。本文的目的是调查将吡唑结构与对应于9种不同类型癌症的抗癌活性联系起来的最新研究成果。

更新日期：2019-12-17

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