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Engineering H2O2 Self-Supplying Nanotheranostic Platform for Targeted and Imaging-Guided Chemodynamic Therapy.
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2019-12-30 , DOI: 10.1021/acsami.9b18676
Yajing Han 1 , Jiang Ouyang 2 , Yazhou Li 1 , Fenglin Wang 1 , Jian-Hui Jiang 1
Affiliation  

Developing highly efficient chemodynamic therapy (CDT)-based theranostic technology for cancer treatment is highly desired but still challenging. A novel nanotheranostic platform is constructed for enhanced CDT by engineering hybrid CaO2 and Fe3O4 nanoparticles with a hyaluronate acid (HA) stabilizer and NIR fluorophore label. This design not only enables the nanotheranostic agent to afford highly efficient CDT against tumor cells but also confers NIR fluorescence (NIRF) and magnetic resonance (MR) bimodal imaging for in vivo visualization of CDT. Moreover, the use of the HA stabilizer allows for the facile synthesis of the nanotheranostic agent with excellent biocompatibility and active targetability. The nanotheranaostic agent possesses a high capacity of self-supplying H2O2 and producing •OH in acidic conditions, while retaining the desired stability under physiological conditions. It also demonstrates high selectivity to tumor cells via CDT with minimized toxicity to normal cells. In vivo studies reveal that our nanotheranaostic agent exhibits efficacious tumor growth inhibition via a CDT mechanism with favorable biosafety. Moreover, in vivo visualization of the CDT progress via NIRF and MR bimodal imaging demonstrates specific targeting and treatment of tumors. The developed H2O2 self-supplying, active targeting, and bimodal imaging nanotheranostic platform holds the potential as a highly efficient strategy for CDT of cancer.

中文翻译:

工程H2O2自给式纳米治疗平台,用于靶向和影像引导的化学动力学治疗。

迫切需要开发基于高效化学动力学疗法(CDT)的治疗学技术,用于癌症治疗,但仍具有挑战性。通过工程化具有透明质酸(HA)稳定剂和NIR荧光团标记的杂化CaO2和Fe3O4纳米颗粒,构建了用于增强CDT的新型纳米热学平台。这种设计不仅使纳米治疗剂能够提供针对肿瘤细胞的高效CDT,而且还赋予NIR荧光(NIRF)和磁共振(MR)双峰成像技术,以实现CDT的体内可视化。而且,HA稳定剂的使用允许容易地合成具有优异的生物相容性和活性靶向性的纳米热试剂。纳米热解剂在酸性条件下具有自给自足的H2O2和产生•OH的能力,同时在生理条件下保持所需的稳定性。它还显示了通过CDT对肿瘤细胞的高选择性,并且对正常细胞的毒性降至最低。体内研究表明,我们的纳米治疗剂通过具有良好生物安全性的CDT机制表现出有效的肿瘤生长抑制作用。此外,通过NIRF和MR双峰成像对CDT进展进行体内可视化显示了肿瘤的特异性靶向和治疗。先进的H2O2自给,主动靶向和双峰成像纳米热成像平台具有作为癌症CDT高效策略的潜力。体内研究表明,我们的纳米治疗剂通过具有良好生物安全性的CDT机制表现出有效的肿瘤生长抑制作用。此外,通过NIRF和MR双峰成像对CDT进展进行体内可视化显示了肿瘤的特异性靶向和治疗。先进的H2O2自给,主动靶向和双峰成像纳米热成像平台具有作为癌症CDT高效策略的潜力。体内研究表明,我们的纳米治疗剂通过具有良好生物安全性的CDT机制表现出有效的肿瘤生长抑制作用。此外,通过NIRF和MR双峰成像对CDT进展进行体内可视化显示了肿瘤的特异性靶向和治疗。先进的H2O2自给,主动靶向和双峰成像纳米热成像平台具有作为癌症CDT高效策略的潜力。
更新日期:2019-12-30
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