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Enlarged subarachnoid space on cranial ultrasound in preterm infants: Neurodevelopmental implication.
Scientific Reports ( IF 3.8 ) Pub Date : 2019-12-13 , DOI: 10.1038/s41598-019-55604-x Sook Kyung Yum 1 , Soo Ah Im 2 , Yu Mi Seo 1 , In Kyung Sung 1
Scientific Reports ( IF 3.8 ) Pub Date : 2019-12-13 , DOI: 10.1038/s41598-019-55604-x Sook Kyung Yum 1 , Soo Ah Im 2 , Yu Mi Seo 1 , In Kyung Sung 1
Affiliation
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The role of enlarged subarachnoid space (ESS) in preterm infants has not been described in concrete. We aimed to evaluate whether ESS should be considered a risk factor potentially associated with adverse neurodevelopmental outcomes in prematurity. Electronic medical records of 197 preterm infants (median 32.1 weeks' gestation) including cranial ultrasound (cUS) images, head circumferences, and Korean Developmental Screening Tests for Infants and Children (K-DST) results at 18-24 months corrected age were reviewed. The clinical characteristics and K-DST results were compared in infants with and without ESS (sinocortical width > 3.5 mm). A multivariable logistic regression analysis was performed to identify potential risk factors associated with positive K-DST results. At a median corrected age of 39.0 weeks, 81/197 (41.1%) infants presented ESS. A significantly greater percent of infants in the ESS group screened positive on the K-DST than in the no ESS group (27.2% vs 12.1%, p = 0.007). Within the ESS group, micro-/macrocephaly at term-equivalent age was not different with regard to the K-DST results. From the multivariable logistic regression analysis, gestational age (p = 0.016, OR = 0.855, 95% CI = 0.753-0.971) and ESS (p = 0.019, OR = 1.310, 95% CI = 1.046-1.641) were two significant risk factors associated with positive K-DST results. ESS identified on cUS at term-equivalent age in preterm infants is associated with possible developmental delays. Macrocephaly at term-equivalent age does not guarantee a benign prognosis. Future studies are required to verify ESS as a potential marker for neurodevelopmental delay in preterm infants.
中文翻译：
早产儿颅内超声下蛛网膜下腔的扩大：神经发育的意义。
尚未具体描述扩大的蛛网膜下腔（ESS）在早产儿中的作用。我们旨在评估是否应将ESS视为与早产不良神经发育结果潜在相关的危险因素。回顾了197例早产儿（妊娠中位32.1周）的电子病历，包括颅内超声（cUS）图像，头围和18-24个月校正年龄的韩国婴儿发育筛查测试（K-DST）结果。比较了有和没有ESS（鼻窦皮质宽度> 3.5 mm）的婴儿的临床特征和K-DST结果。进行了多变量logistic回归分析，以确定与阳性K-DST结果相关的潜在危险因素。矫正年龄中位数为39.0周，为81/197（41。1％）的婴儿出现了ESS。ESS组婴儿的K-DST筛查阳性率高于无ESS组（27.2％比12.1％，p = 0.007）。在ESS组中，就K-DST结果而言，足月等效年龄的微头/巨头畸形没有差异。从多变量logistic回归分析来看，胎龄（p = 0.016，OR = 0.855，95％CI = 0.753-0.971）和ESS（p = 0.019，OR = 1.310，95％CI = 1.046-1.641）是两个重要的危险因素与积极的K-DST结果相关。在足月等效年龄的cUS上通过cUS鉴定的ESS与可能的发育延迟有关。足当量年龄的大头畸形不能保证预后良好。需要进一步的研究来验证ESS作为早产儿神经发育延迟的潜在标志物。ESS组婴儿的K-DST筛查阳性率高于无ESS组（27.2％比12.1％，p = 0.007）。在ESS组中，就K-DST结果而言，足月等效年龄的微头/巨头畸形没有差异。从多变量logistic回归分析来看，胎龄（p = 0.016，OR = 0.855，95％CI = 0.753-0.971）和ESS（p = 0.019，OR = 1.310，95％CI = 1.046-1.641）是两个重要的危险因素与积极的K-DST结果相关。在足月等效年龄的cUS上通过cUS鉴定的ESS与可能的发育延迟有关。足当量年龄的大头畸形不能保证预后良好。需要进一步的研究来验证ESS作为早产儿神经发育延迟的潜在标志物。ESS组婴儿的K-DST筛查阳性率高于无ESS组（27.2％比12.1％，p = 0.007）。在ESS组中，就K-DST结果而言，足月等效年龄的微头/巨头畸形没有差异。从多变量logistic回归分析来看，胎龄（p = 0.016，OR = 0.855，95％CI = 0.753-0.971）和ESS（p = 0.019，OR = 1.310，95％CI = 1.046-1.641）是两个重要的危险因素与积极的K-DST结果相关。在足月等效年龄的cUS上通过cUS鉴定的ESS与可能的发育延迟有关。足当量年龄的大头畸形不能保证预后良好。需要进一步的研究来验证ESS作为早产儿神经发育延迟的潜在标志物。
更新日期：2019-12-13
中文翻译：
早产儿颅内超声下蛛网膜下腔的扩大：神经发育的意义。
尚未具体描述扩大的蛛网膜下腔（ESS）在早产儿中的作用。我们旨在评估是否应将ESS视为与早产不良神经发育结果潜在相关的危险因素。回顾了197例早产儿（妊娠中位32.1周）的电子病历，包括颅内超声（cUS）图像，头围和18-24个月校正年龄的韩国婴儿发育筛查测试（K-DST）结果。比较了有和没有ESS（鼻窦皮质宽度> 3.5 mm）的婴儿的临床特征和K-DST结果。进行了多变量logistic回归分析，以确定与阳性K-DST结果相关的潜在危险因素。矫正年龄中位数为39.0周，为81/197（41。1％）的婴儿出现了ESS。ESS组婴儿的K-DST筛查阳性率高于无ESS组（27.2％比12.1％，p = 0.007）。在ESS组中，就K-DST结果而言，足月等效年龄的微头/巨头畸形没有差异。从多变量logistic回归分析来看，胎龄（p = 0.016，OR = 0.855，95％CI = 0.753-0.971）和ESS（p = 0.019，OR = 1.310，95％CI = 1.046-1.641）是两个重要的危险因素与积极的K-DST结果相关。在足月等效年龄的cUS上通过cUS鉴定的ESS与可能的发育延迟有关。足当量年龄的大头畸形不能保证预后良好。需要进一步的研究来验证ESS作为早产儿神经发育延迟的潜在标志物。ESS组婴儿的K-DST筛查阳性率高于无ESS组（27.2％比12.1％，p = 0.007）。在ESS组中，就K-DST结果而言，足月等效年龄的微头/巨头畸形没有差异。从多变量logistic回归分析来看，胎龄（p = 0.016，OR = 0.855，95％CI = 0.753-0.971）和ESS（p = 0.019，OR = 1.310，95％CI = 1.046-1.641）是两个重要的危险因素与积极的K-DST结果相关。在足月等效年龄的cUS上通过cUS鉴定的ESS与可能的发育延迟有关。足当量年龄的大头畸形不能保证预后良好。需要进一步的研究来验证ESS作为早产儿神经发育延迟的潜在标志物。ESS组婴儿的K-DST筛查阳性率高于无ESS组（27.2％比12.1％，p = 0.007）。在ESS组中，就K-DST结果而言，足月等效年龄的微头/巨头畸形没有差异。从多变量logistic回归分析来看，胎龄（p = 0.016，OR = 0.855，95％CI = 0.753-0.971）和ESS（p = 0.019，OR = 1.310，95％CI = 1.046-1.641）是两个重要的危险因素与积极的K-DST结果相关。在足月等效年龄的cUS上通过cUS鉴定的ESS与可能的发育延迟有关。足当量年龄的大头畸形不能保证预后良好。需要进一步的研究来验证ESS作为早产儿神经发育延迟的潜在标志物。
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