Chiral phosphoric acid-catalyzed asymmetric dearomatization reactions.,Chemical Society Reviews

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Chiral phosphoric acid-catalyzed asymmetric dearomatization reactions.
Chemical Society Reviews ( IF 40.4 ) Pub Date : 2020-01-02 , DOI: 10.1039/c8cs00436f
Zi-Lei Xia ₁ , Qing-Feng Xu-Xu , Chao Zheng , Shu-Li You

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We summarize in this review the recent development of chiral phosphoric acid (CPA)-catalyzed asymmetric dearomatization reactions. A wide array of electron-rich arenes (indoles, phenols, naphthols, benzothiophenes, benzofurans, etc.) and electron-poor arenes (pyridines, quinolines, isoquinolines, etc.) has been proved reactive towards various reaction partners in the presence of a CPA catalyst, enabling asymmetric dearomatization reactions that lead to structurally-diverse polycyclic molecules. The reactions are grouped according to the roles of the arenes in the reactions (as nucleophiles or electrophiles) and the types of reaction partners. This review closes with a personal perspective on the dynamic research area of asymmetric dearomatization reactions by CPAs.

中文翻译：

手性磷酸催化的不对称脱芳香化反应。

我们在这篇综述中总结了手性磷酸（CPA）催化不对称脱芳香化反应的最新进展。业已证明，存在大量电子富集芳烃（吲哚，苯酚，萘，苯并噻吩，苯并呋喃等）和贫电子芳烃（吡啶，喹啉，异喹啉等）对多种反应伙伴均具有反应活性。 CPA催化剂，可进行不对称的脱芳香化反应，从而导致结构多样的多环分子。根据芳烃在反应中的作用（亲核试剂或亲电试剂）和反应伙伴的类型对反应进行分组。本文以个人观点结束了CPAs不对称脱芳香化反应的动态研究领域。

更新日期：2020-01-02

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