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One-component waterborne in vivo cross-linkable polysiloxane coatings for artificial skin.
Journal of Biomedical Materials Research Part B: Applied Biomaterials ( IF 3.2 ) Pub Date : 2019-12-09 , DOI: 10.1002/jbm.b.34517 Ping Li 1 , Ailing Zhang 1 , Shuxue Zhou 1
Journal of Biomedical Materials Research Part B: Applied Biomaterials ( IF 3.2 ) Pub Date : 2019-12-09 , DOI: 10.1002/jbm.b.34517 Ping Li 1 , Ailing Zhang 1 , Shuxue Zhou 1
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Polysiloxane‐based artificial skins are able to emulate the mechanical and barrier performance of human skin. However, they are usually fabricated in vitro, restricting their diverse applications on human body. Herein, we presented one‐component waterborne cross‐linkable polysiloxane coatings prepared from emulsified vinyl dimethicone, emulsified hydrogen dimethicone, and Karstedt catalyst capsules that were first synthesized by solvent evaporation method. The coating had good storage stability and meanwhile could form an elastic film quickly through merging of silicone oil droplets and subsequent hydrosilylation reaction. It was found that the mass ratio of vinyl dimethicone emulsion/hydrogen dimethicone emulsion (V/H), and the dosage of Karstedt catalyst capsules (K/(V + H)) were critical to the curing time, morphology, and mechanical properties of the coatings. With appropriate values of V/H and K/(V + H), the polysiloxane film had the mechanical performance comparable to that from solvent‐based one. The coating could be topically applied to human skin in vivo and in situ turned into an elastic, invisible thin film with good water resistance. In contrast to those reported polysiloxane materials, the one‐component waterborne polysiloxane coating was nontoxic and convenient for in vivo application on human body, making it be a promising candidate as artificial skin in the fields of cosmetics, medical treatment, and E‐skin.
中文翻译：
用于人造皮肤的单组分水性体内可交联聚硅氧烷涂料。
基于聚硅氧烷的人造皮肤能够模拟人类皮肤的机械和屏障性能。然而，它们通常是在体外制造的，限制了它们在人体上的多样化应用。在此，我们提出了由乳化乙烯基聚二甲基硅氧烷、乳化氢聚二甲基硅氧烷和 Karstedt 催化剂胶囊制备的单组分水性可交联聚硅氧烷涂料，这些涂料首先通过溶剂蒸发法合成。该涂层具有良好的储存稳定性，同时可以通过硅油液滴的合并和随后的氢化硅烷化反应快速形成弹性薄膜。发现乙烯基聚二甲基硅氧烷乳液/氢聚二甲基硅氧烷乳液的质量比 (V/H) 和 Karstedt 催化剂胶囊的用量 (K/(V + H)) 对固化时间、形貌和机械性能至关重要。涂料。使用适当的 V/H 和 K/(V + H) 值，聚硅氧烷薄膜的机械性能与溶剂型薄膜相当。该涂层可局部应用于人体皮肤在体内和原位变成具有良好防水性的弹性隐形薄膜。与报道的聚硅氧烷材料相比，单组分水性聚硅氧烷涂层无毒且便于在体内应用于人体，使其成为化妆品、医疗和电子皮肤领域的人造皮肤的有希望的候选者。
更新日期：2019-12-09
中文翻译：
用于人造皮肤的单组分水性体内可交联聚硅氧烷涂料。
基于聚硅氧烷的人造皮肤能够模拟人类皮肤的机械和屏障性能。然而，它们通常是在体外制造的，限制了它们在人体上的多样化应用。在此，我们提出了由乳化乙烯基聚二甲基硅氧烷、乳化氢聚二甲基硅氧烷和 Karstedt 催化剂胶囊制备的单组分水性可交联聚硅氧烷涂料，这些涂料首先通过溶剂蒸发法合成。该涂层具有良好的储存稳定性，同时可以通过硅油液滴的合并和随后的氢化硅烷化反应快速形成弹性薄膜。发现乙烯基聚二甲基硅氧烷乳液/氢聚二甲基硅氧烷乳液的质量比 (V/H) 和 Karstedt 催化剂胶囊的用量 (K/(V + H)) 对固化时间、形貌和机械性能至关重要。涂料。使用适当的 V/H 和 K/(V + H) 值，聚硅氧烷薄膜的机械性能与溶剂型薄膜相当。该涂层可局部应用于人体皮肤在体内和原位变成具有良好防水性的弹性隐形薄膜。与报道的聚硅氧烷材料相比，单组分水性聚硅氧烷涂层无毒且便于在体内应用于人体，使其成为化妆品、医疗和电子皮肤领域的人造皮肤的有希望的候选者。
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