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The autophagy receptor p62/SQST-1 promotes proteostasis and longevity in C. elegans by inducing autophagy.
Nature Communications ( IF 14.7 ) Pub Date : 2019-12-11 , DOI: 10.1038/s41467-019-13540-4 Caroline Kumsta 1 , Jessica T Chang 1 , Reina Lee 1 , Ee Phie Tan 1 , Yongzhi Yang 1 , Rute Loureiro 2 , Elizabeth H Choy 1 , Shaun H Y Lim 1 , Isabel Saez 2 , Alexander Springhorn 2 , Thorsten Hoppe 2 , David Vilchez 2 , Malene Hansen 1
Nature Communications ( IF 14.7 ) Pub Date : 2019-12-11 , DOI: 10.1038/s41467-019-13540-4 Caroline Kumsta 1 , Jessica T Chang 1 , Reina Lee 1 , Ee Phie Tan 1 , Yongzhi Yang 1 , Rute Loureiro 2 , Elizabeth H Choy 1 , Shaun H Y Lim 1 , Isabel Saez 2 , Alexander Springhorn 2 , Thorsten Hoppe 2 , David Vilchez 2 , Malene Hansen 1
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Autophagy can degrade cargos with the help of selective autophagy receptors such as p62/SQSTM1, which facilitates the degradation of ubiquitinated cargo. While the process of autophagy has been linked to aging, the impact of selective autophagy in lifespan regulation remains unclear. We have recently shown in Caenorhabditis elegans that transcript levels of sqst-1/p62 increase upon a hormetic heat shock, suggesting a role of SQST-1/p62 in stress response and aging. Here, we find that sqst-1/p62 is required for hormetic benefits of heat shock, including longevity, improved neuronal proteostasis, and autophagy induction. Furthermore, overexpression of SQST-1/p62 is sufficient to induce autophagy in distinct tissues, extend lifespan, and improve the fitness of mutants with defects in proteostasis in an autophagy-dependent manner. Collectively, these findings illustrate that increased expression of a selective autophagy receptor is sufficient to induce autophagy, enhance proteostasis and extend longevity, and demonstrate an important role for sqst-1/p62 in proteotoxic stress responses.
中文翻译：
自噬受体p62 / SQST-1通过诱导自噬促进秀丽隐杆线虫的蛋白稳态和长寿。
自噬可以借助选择性自噬受体（例如p62 / SQSTM1）降解货物，这可以促进泛素化货物的降解。尽管自噬过程与衰老有关，但选择性自噬在寿命调节中的影响仍不清楚。我们最近在秀丽隐杆线虫中显示，在剧烈的热休克后，sqst-1 / p62的转录水平会增加，这表明SQST-1 / p62在应激反应和衰老中的作用。在这里，我们发现sqst-1 / p62是热休克带来的有益益处（包括寿命长，神经元蛋白水解性改善和自噬诱导）所必需的。此外，SQST-1 / p62的过表达足以在不同组织中诱导自噬，延长寿命，并以自噬依赖性方式改善蛋白稳定中有缺陷的突变体的适应性。总的来说，
更新日期：2019-12-11
中文翻译：
自噬受体p62 / SQST-1通过诱导自噬促进秀丽隐杆线虫的蛋白稳态和长寿。
自噬可以借助选择性自噬受体（例如p62 / SQSTM1）降解货物，这可以促进泛素化货物的降解。尽管自噬过程与衰老有关，但选择性自噬在寿命调节中的影响仍不清楚。我们最近在秀丽隐杆线虫中显示，在剧烈的热休克后，sqst-1 / p62的转录水平会增加，这表明SQST-1 / p62在应激反应和衰老中的作用。在这里，我们发现sqst-1 / p62是热休克带来的有益益处（包括寿命长，神经元蛋白水解性改善和自噬诱导）所必需的。此外，SQST-1 / p62的过表达足以在不同组织中诱导自噬，延长寿命，并以自噬依赖性方式改善蛋白稳定中有缺陷的突变体的适应性。总的来说，
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