Manipulating exciton dynamics of thermally activated delayed fluorescence materials for tuning two-photon nanotheranostics†,Chemical Science

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Manipulating exciton dynamics of thermally activated delayed fluorescence materials for tuning two-photon nanotheranostics†
Chemical Science ( IF 7.6 ) Pub Date : 2019-12-11 , DOI: 10.1039/c9sc05817f
Ya-Fang Xiao _{1,

2,

3,

4,

5} , Jia-Xiong Chen _{1,

2,

3,

4,

5} , Shengliang Li _{1,

2,

3,

4,

5} , Wen-Wen Tao _{6,

7,

8,

9,

10} , Shuang Tian _{1,

2,

3,

4,

5} , Kai Wang _{6,

7,

8,

9,

10} , Xiao Cui _{1,

2,

3,

4,

5} , Zhongming Huang _{1,

2,

3,

4,

5} , Xiao-Hong Zhang _{6,

7,

8,

9,

10} , Chun-Sing Lee _{1,

2,

3,

4,

5}

Affiliation

Rational manipulation of energy utilization from excited-state radiation of theranostic agents with a donor–acceptor structure is relatively unexplored. Herein, we present an effective strategy to tune the exciton dynamics of radiative excited state decay for augmenting two-photon nanotheranostics. As a proof of concept, two thermally activated delayed fluorescence (TADF) molecules with different electron-donating segments are engineered, which possess donor–acceptor structures and strong emissions in the deep-red region with aggregation-induced emission characteristics. Molecular simulations demonstrate that change of the electron-donating sections could effectively regulate the singlet–triplet energy gap and oscillator strength, which promises efficient energy flow. A two-photon laser with great permeability is used to excite TADF NPs to perform as theranostic agents with singlet oxygen generation and fluorescence imaging. These unique performances enable the proposed TADF emitters to exhibit tailored balances between two-photon singlet oxygen generation and fluorescence emission. This result demonstrates that TADF emitters can be rationally designed as superior candidates for nanotheranostic agents by the custom controlling exciton dynamics.

中文翻译：

操纵热活化延迟荧光材料的激子动力学，以调节双光子纳米热力学†

尚无人对具有供体-受体结构的治疗剂的激发态辐射进行合理的能量利用控制。在这里，我们提出了一种有效的策略，以调整激子激发态衰变的激子动力学，以增强双光子纳米热力学。作为概念证明，设计了两个具有不同电子给体链段的热激活延迟荧光（TADF）分子，它们具有供体-受体结构，并在深红色区域具有聚集诱导的发射特性，具有强发射。分子模拟表明，给电子区的变化可以有效地调节单重态-三重态的能隙和振荡器强度，从而保证有效的能量流。具有高磁导率的两光子激光器用于激发TADF NP，以用作治疗血红蛋白的试剂，产生单线态氧并进行荧光成像。这些独特的性能使建议的TADF发射器能够在双光子单线态氧的产生和荧光发射之间展现出定制的平衡。该结果表明，通过自定义控制激子动力学，可以合理地将TADF发射体设计为纳米热敏剂的优良候选者。

更新日期：2019-12-11

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