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Ischemic Stroke Risk in Patients With Nonvalvular Atrial Fibrillation
Journal of the American College of Cardiology ( IF 21.7 ) Pub Date : 2019-12-01 , DOI: 10.1016/j.jacc.2019.10.040 Mohamad Alkhouli 1 , Paul A Friedman 1
Journal of the American College of Cardiology ( IF 21.7 ) Pub Date : 2019-12-01 , DOI: 10.1016/j.jacc.2019.10.040 Mohamad Alkhouli 1 , Paul A Friedman 1
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The last decade has witnessed remarkable advances in pharmacological and nonpharmacological strategies for stroke prevention in patients with atrial fibrillation. However, the currently available clinical stroke risk prediction models do not account for key nonclinical factors (arrhythmia burden, left atrial physiology and anatomy, chemical and electrocardiographic markers) and other competing clinical risks. Hence, their ability to identify patients who will derive the most benefit from pharmacological and mechanical risk prevention strategies remain limited. In this paper, the authors review the current and evolving ischemic stroke risk prediction schemes in patients with nonvalvular atrial fibrillation, highlight the strengths and weaknesses of the models, and discuss the unmet needs in this field.
中文翻译：
非瓣膜性房颤患者的缺血性卒中风险
过去十年见证了房颤患者卒中预防的药物和非药物策略取得显着进展。然而，目前可用的临床卒中风险预测模型并未考虑关键的非临床因素（心律失常负担、左心房生理和解剖、化学和心电图标志物）和其他竞争性临床风险。因此，他们识别将从药物和机械风险预防策略中获得最大益处的患者的能力仍然有限。在本文中，作者回顾了非瓣膜性房颤患者当前和不断发展的缺血性卒中风险预测方案，强调了模型的优缺点，并讨论了该领域未满足的需求。
更新日期：2019-12-01
中文翻译：
非瓣膜性房颤患者的缺血性卒中风险
过去十年见证了房颤患者卒中预防的药物和非药物策略取得显着进展。然而，目前可用的临床卒中风险预测模型并未考虑关键的非临床因素（心律失常负担、左心房生理和解剖、化学和心电图标志物）和其他竞争性临床风险。因此，他们识别将从药物和机械风险预防策略中获得最大益处的患者的能力仍然有限。在本文中，作者回顾了非瓣膜性房颤患者当前和不断发展的缺血性卒中风险预测方案，强调了模型的优缺点，并讨论了该领域未满足的需求。
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