Molecular glue concept solidifies.,Nature Chemical Biology

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Molecular glue concept solidifies.
Nature Chemical Biology ( IF 12.9 ) Pub Date : 2020-01-01 , DOI: 10.1038/s41589-019-0414-3
Kheewoong Baek ₁ , Brenda A Schulman ₁

Affiliation

Molecular-glue-mediated proximity-induced degradation now allows unprecedented therapeutic targeting of previously undruggable proteins. Structures showing how aryl-sulfonamides mediate recruitment of the splicing factor RBM39 to the E3 CRL4DCAF15 broaden the mechanistic principles by which molecular glues target ubiquitylation.

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