One new type of electrochemical sensors for the effective glucose detection is fabricated based on the use of CuO_x@Co₃O₄ core-shell nanowires on Cu foam as electrocatalysts, which is synthesized through the stepwise process, including anodized nano-sized Cu(OH)₂ wires, Metal-organic frameworks (MOFs)-wrapped Cu(OH)₂ nanowires, and the following calcination. These as-made hierarchical composites exhibit the structural characteristics of CuO_x nanowires core and Co₃O₄ nanoparticles shell calcinated from the terminally attached microporous ZIF-67. This type of glucose sensor compared to pure individual metal oxides exhibits higher sensitivity (27778 μA mM^-1 cm^-2 in the range from 0.1 to 1300.0 μM), lower detection limit (36 nM (S/N = 3)) and faster response time (˜1 s), also displays satisfactory selectivity, reproducibility, and long-term storage stability. Meanwhile, it achieves well-pleasing results in the detection of glucose in real human blood serum compared to commercial sensors. In addition, other four types of self-supporting MOF-derived bimetallic oxides core-shell nanowire arrays on Cu foam are also prepared by adopting the similar three-step procedure, including CuO_x@Fe₂O₃, CuO_x@NiO, CuO_x@CuO_x and CuO_x@ZnO core-shell nanowires, demonstrating the versatility of this method. These results confirm that our as-made MOF-derived bimetallic oxide based sensor of CuO_x@Co₃O₄ has a great potential application in the development of enzyme-free sensors for monitoring glucose.

基于Cu泡沫上的CuO _x @Co ₃ O ₄核壳纳米线作为电催化剂，利用逐步氧化法合成了一种新型的电化学传感器，用于葡萄糖的有效检测，包括阳极氧化的纳米级Cu（ OH）₂线，金属有机骨架（MOF）包裹的Cu（OH）₂纳米线和以下煅烧。这些制成的分层复合材料具有CuO _x纳米线芯和Co ₃ O ₄的结构特征。从末端附着的微孔ZIF-67煅烧的纳米颗粒壳。与纯单独的金属氧化物相比，这种类型的葡萄糖传感器具有更高的灵敏度（27778μAmM ^-1  cm ^-2，范围从0.1到1300.0μM），更低的检测限（36 nM（S / N = 3））和更快的响应速度时间（〜1s），还显示令人满意的选择性，可再现性和长期储存稳定性。同时，与商用传感器相比，它在检测真实人血清中的葡萄糖方面取得了令人愉悦的结果。此外，还通过采用类似的三步法（包括CuO _x @Fe ₂ O _3）制备了其他四种类型的自支撑MOF衍生的双金属氧化物双金属氧化物核壳纳米线阵列。，CuO _x @ NiO，CuO _x @CuO _x和CuO _x @ZnO核壳纳米线，证明了该方法的多功能性。这些结果证实，我们的基于MOF的基于双金属氧化物的CuO _x @Co ₃ O ₄传感器在开发用于监测葡萄糖的无酶传感器方面具有巨大的潜在应用前景。