当前位置：
X-MOL 学术
›
Bioorgan. Chem.
›
论文详情
Our official English website, www.x-mol.net, welcomes your
feedback! (Note: you will need to create a separate account there.)
Isoquinolines from national herb Corydalis tomentella and neuroprotective effect against lipopolysaccharide-induced BV2 microglia cells.
Bioorganic Chemistry ( IF 4.5 ) Pub Date : 2019-12-09 , DOI: 10.1016/j.bioorg.2019.103489 Yu-Meng Wang 1 , Wen-Zhuo Ming 1 , Hui Liang 1 , Ying-Jiao Wang 1 , Yun-Hong Zhang 1 , Da-Li Meng 1
Bioorganic Chemistry ( IF 4.5 ) Pub Date : 2019-12-09 , DOI: 10.1016/j.bioorg.2019.103489 Yu-Meng Wang 1 , Wen-Zhuo Ming 1 , Hui Liang 1 , Ying-Jiao Wang 1 , Yun-Hong Zhang 1 , Da-Li Meng 1
Affiliation
|
Five new isoquinolines (1-5) were isolated from national herb Corydalis tomentella. Their structures were elucidated by extensive analysis of the 1D and 2D NMR spectra and from the HRESIMS. Absolute configurations of 1-3 were determined by comparing their experimental and computed ECD data. Since plants from Corydalis have been reported to protect against Alzheimer's disease, all compounds were evaluated for their neuroprotective effect against lipopolysaccharide-induced BV2 microglia cells. Compound 2 and 3 showed well anti-neuroinflammatory activity at low concentration (25 μM).
中文翻译：
来自国家草药延胡索的异喹啉和对脂多糖诱导的BV2小胶质细胞的神经保护作用。
从国家草药延胡索中分离出五种新的异喹啉（1-5）。通过对1D和2D NMR光谱以及HRESIMS的广泛分析，阐明了它们的结构。通过比较其实验数据和计算得出的ECD数据，可以确定1-3的绝对构型。由于据报道，延胡索植物可预防阿尔茨海默氏病，因此评估了所有化合物对脂多糖诱导的BV2小胶质细胞的神经保护作用。化合物2和3在低浓度（25μM）下表现出良好的抗神经炎活性。
更新日期：2019-12-09
中文翻译：
来自国家草药延胡索的异喹啉和对脂多糖诱导的BV2小胶质细胞的神经保护作用。
从国家草药延胡索中分离出五种新的异喹啉（1-5）。通过对1D和2D NMR光谱以及HRESIMS的广泛分析，阐明了它们的结构。通过比较其实验数据和计算得出的ECD数据，可以确定1-3的绝对构型。由于据报道，延胡索植物可预防阿尔茨海默氏病，因此评估了所有化合物对脂多糖诱导的BV2小胶质细胞的神经保护作用。化合物2和3在低浓度（25μM）下表现出良好的抗神经炎活性。
京公网安备 11010802027423号