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Therapeutic options and drug delivery strategies for the prevention of intrauterine adhesions.
Journal of Controlled Release ( IF 10.5 ) Pub Date : 2019-12-09 , DOI: 10.1016/j.jconrel.2019.12.007 Longfa Kou 1 , Xue Jiang 2 , Shuyi Xiao 1 , Ying-Zheng Zhao 2 , Qing Yao 2 , Ruijie Chen 1
Journal of Controlled Release ( IF 10.5 ) Pub Date : 2019-12-09 , DOI: 10.1016/j.jconrel.2019.12.007 Longfa Kou 1 , Xue Jiang 2 , Shuyi Xiao 1 , Ying-Zheng Zhao 2 , Qing Yao 2 , Ruijie Chen 1
Affiliation
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Intrauterine adhesions (IUAs) are bands of fibrous tissue that form in the endometrial cavity and associated with the increased risk of abnormal menstruation, recurrent pregnancy loss, secondary infertility, and pregnancy complications. Physical barriers, including intrauterine device and hydrogel, were clinical available to prevent the post-operational IUAs. But physically separation of the injured endometrium relies on the own limited healing power and often ends with recurrence. In recent years, the mechanisms driving IUAs treatment has validated the application of hormones, and further stem cell therapy has also led to the development of novel therapeutic agents with promising efficacy in pre-clinical and initial clinical studies. Still, it is challenging to delivery the therpaeutic factors to the injured uterus. Herein, in this review, we discuss the traditional intervention methods for the prevention of IUAs, as well as novel therapeutics and delivery strategies that will most likely change the treatment paradigms for better clinical outcomes. The combination strategy that using physical barriers as the delivery carriers for therapeutics might provide new alternatives for the prevention of IUAs.
中文翻译：
预防宫腔粘连的治疗选择和给药策略。
子宫内粘连（IUA）是在子宫内膜腔中形成的纤维组织带，与月经异常，再次妊娠流产，继发性不孕和妊娠并发症的风险增加有关。临床上可以使用物理障碍，包括宫内节育器和水凝胶来预防术后IUA。但是，受伤的子宫内膜在物理上的分离取决于自身有限的愈合能力，并且往往以复发而告终。近年来，驱动IUAs治疗的机制已验证了激素的应用，进一步的干细胞治疗也导致了在临床前和初始临床研究中具有前景良好的新型治疗剂的开发。尽管如此，将治疗因子输送到受伤的子宫仍具有挑战性。在这里，在这篇评论中，我们讨论了预防IUA的传统干预方法，以及新颖的治疗方法和给药策略，这些策略和方法很可能会改变治疗范例，以取得更好的临床效果。使用物理屏障作为治疗剂的传递载体的联合策略可能为预防IUA提供新的选择。
更新日期：2019-12-09
中文翻译：
预防宫腔粘连的治疗选择和给药策略。
子宫内粘连（IUA）是在子宫内膜腔中形成的纤维组织带，与月经异常，再次妊娠流产，继发性不孕和妊娠并发症的风险增加有关。临床上可以使用物理障碍，包括宫内节育器和水凝胶来预防术后IUA。但是，受伤的子宫内膜在物理上的分离取决于自身有限的愈合能力，并且往往以复发而告终。近年来，驱动IUAs治疗的机制已验证了激素的应用，进一步的干细胞治疗也导致了在临床前和初始临床研究中具有前景良好的新型治疗剂的开发。尽管如此，将治疗因子输送到受伤的子宫仍具有挑战性。在这里，在这篇评论中，我们讨论了预防IUA的传统干预方法，以及新颖的治疗方法和给药策略，这些策略和方法很可能会改变治疗范例，以取得更好的临床效果。使用物理屏障作为治疗剂的传递载体的联合策略可能为预防IUA提供新的选择。
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