Pd(0)-Catalyzed Intramolecular "Ylide-Ullmann-Type" Cyclization of Carbonyl-Stabilized Phosphonium Ylides and Access to Phosphachromones by Exocyclic P-C Cleavage.,Organic Letters

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Pd(0)-Catalyzed Intramolecular "Ylide-Ullmann-Type" Cyclization of Carbonyl-Stabilized Phosphonium Ylides and Access to Phosphachromones by Exocyclic P-C Cleavage.
Organic Letters ( IF 4.9 ) Pub Date : 2019-12-06 , DOI: 10.1021/acs.orglett.9b03948
Shuangshuang Xu ₁ , Haiyang Huang ₁ , Zeen Yan ₁ , Qiang Xiao ₁

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An unprecedented palladium-catalyzed intramolecular Ullmann-type cyclization of carbonyl-stabilized phosphonium ylides with aryl bromides was successfully developed. Furthermore, a base-promoted chemoselective hydrolysis of exocyclic P-C bond of the corresponding phosphonium salts delivered various phosphachromones. Excellent selectivity and high efficiency and good functional group tolerance were observed.

中文翻译：

Pd（0）催化的羰基稳定化的磷化叶立德的分子内“ Ylide-Ullmann型”环化反应以及通过环外PC裂解获得磷色酮。

成功开发了前所未有的钯催化羰基稳定的磷化膦与芳基溴化物的分子内Ullmann型环化反应。此外，相应phospho盐的环外PC键的碱促进的化学选择性水解递送了各种膦色酮。观察到优异的选择性和高效率以及良好的官能团耐受性。

更新日期：2019-12-06

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