Antibiotic-Free Antibacterial Strategies Enabled by Nanomaterials: Progress and Perspectives.,Advanced Materials

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Antibiotic-Free Antibacterial Strategies Enabled by Nanomaterials: Progress and Perspectives.
Advanced Materials ( IF 27.4 ) Pub Date : 2019-12-03 , DOI: 10.1002/adma.201904106
Yue Wang ₁ , Yannan Yang ₁ , Yiru Shi ₁ , Hao Song ₁ , Chengzhong Yu _{1,

2}

Affiliation

Bacterial infection is one of the top ten leading causes of death globally and the worst killer in low-income countries. The overuse of antibiotics leads to ever-increasing antibiotic resistance, posing a severe threat to human health. Recent advances in nanotechnology provide new opportunities to address the challenges in bacterial infection by killing germs without using antibiotics. Antibiotic-free antibacterial strategies enabled by advanced nanomaterials are presented. Nanomaterials are classified on the basis of their mode of action: nanomaterials with intrinsic or light-mediated bactericidal properties and others that serve as vehicles for the delivery of natural antibacterial compounds. Specific attention is given to antibacterial mechanisms and the structure-performance relationship. Practical antibacterial applications employing these antibiotic-free strategies are also introduced. Current challenges in this field and future perspectives are presented to stimulate new technologies and their translation to fight against bacterial infection.

中文翻译：

纳米材料实现的无抗生素抗菌策略：进展与展望。

细菌感染是全球十大主要死亡原因之一，也是低收入国家最致命的杀手。过度使用抗生素会导致抗生素耐药性不断提高，对人类健康构成严重威胁。纳米技术的最新进展提供了通过不使用抗生素杀死细菌来应对细菌感染挑战的新机会。提出了由先进的纳米材料实现的无抗生素抗菌策略。纳米材料根据其作用方式进行分类：具有固有或光介导的杀菌特性的纳米材料，以及充当天然抗菌化合物传递媒介的其他材料。特别注意抗菌机理和结构性能关系。还介绍了采用这些无抗生素策略的实际抗菌应用。介绍了该领域的当前挑战和未来前景，以刺激新技术及其翻译以对抗细菌感染。

更新日期：2019-12-03

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