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Autocatalytic Models for the Origin of Biological Homochirality.
Chemical Reviews ( IF 51.4 ) Pub Date : 2019-12-04 , DOI: 10.1021/acs.chemrev.9b00557 Donna G Blackmond 1
Chemical Reviews ( IF 51.4 ) Pub Date : 2019-12-04 , DOI: 10.1021/acs.chemrev.9b00557 Donna G Blackmond 1
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Autocatalytic models for the emergence of homochirality have been of interest for more than half a century. The sole experimental example of such an amplifying autocatalytic reaction is the Soai reaction. In this review, we trace the history of the theoretical models and the experimental work that led up to the discovery of the remarkable, singular Soai reaction. The experimental and computational studies that have helped to delineate the mechanism of this reaction are discussed in detail. Studies of both the concept of chiral symmetry breaking as well as the subsequent chiral amplification process are discussed. Particular attention is paid to flaws in some of the published models, and suggestions are offered for how such issues might be avoided in future work. The outlook in the search for a prebiotically plausible version of such an amplifying autocatalytic system is presented.
中文翻译：
生物同手性起源的自催化模型。
超过半个世纪以来，人们对同手性出现的自动催化模型产生了兴趣。这种放大的自催化反应的唯一实验实例是Soai反应。在这篇综述中，我们追溯了导致发现了惊人的，奇异的Soai反应的理论模型和实验工作的历史。详细讨论了有助于描述该反应机理的实验和计算研究。讨论了对手性对称性断裂概念以及随后的手性扩增过程的研究。特别关注某些已发布模型中的缺陷，并提供了有关如何在将来的工作中避免此类问题的建议。
更新日期：2019-12-04
中文翻译：
生物同手性起源的自催化模型。
超过半个世纪以来，人们对同手性出现的自动催化模型产生了兴趣。这种放大的自催化反应的唯一实验实例是Soai反应。在这篇综述中，我们追溯了导致发现了惊人的，奇异的Soai反应的理论模型和实验工作的历史。详细讨论了有助于描述该反应机理的实验和计算研究。讨论了对手性对称性断裂概念以及随后的手性扩增过程的研究。特别关注某些已发布模型中的缺陷，并提供了有关如何在将来的工作中避免此类问题的建议。
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