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Effect of low-dose Levamlodipine Besylate in the treatment of vascular dementia.
Scientific Reports ( IF 3.8 ) Pub Date : 2019-12-03 , DOI: 10.1038/s41598-019-47868-0 Kai-Xin Yao 1 , Hang Lyu 2 , Mei-Hua Liao 2 , Lin Yang 3 , Yin-Ping Gao 3 , Qi-Bing Liu 4 , Cheng-Kun Wang 2 , Ying-Mei Lu 3 , Guo-Jun Jiang 5 , Feng Han 2 , Ping Wang 1
Scientific Reports ( IF 3.8 ) Pub Date : 2019-12-03 , DOI: 10.1038/s41598-019-47868-0 Kai-Xin Yao 1 , Hang Lyu 2 , Mei-Hua Liao 2 , Lin Yang 3 , Yin-Ping Gao 3 , Qi-Bing Liu 4 , Cheng-Kun Wang 2 , Ying-Mei Lu 3 , Guo-Jun Jiang 5 , Feng Han 2 , Ping Wang 1
Affiliation
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Vascular dementia (VaD) is a complex disorder caused by reduced blood flow in the brain. However, there is no effective pharmacological treatment option available until now. Here, we reported that low-dose levamlodipine besylate could reverse the cognitive impairment in VaD mice model of right unilateral common carotid arteries occlusion (rUCCAO). Oral administration of levamlodipine besylate (0.1 mg/kg) could reduce the latency to find the hidden platform in the MWM test as compared to the vehicle group. Furthermore, vehicle-treated mice revealed reduced phospho-CaMKII (Thr286) levels in the hippocampus, which can be partially restored by levamlodipine besylate (0.1 mg/kg and 0.5 mg/kg) treatment. No significant outcome on microglia and astrocytes were observed following levamlodipine besylate treatment. This data reveal novel findings of the therapeutic potential of low-dose levamlodipine besylate that could considerably enhance the cognitive function in VaD mice.
中文翻译：
小剂量苯磺酸左旋氨氯地平治疗血管性痴呆的效果。
血管性痴呆（VaD）是一种复杂的疾病，由脑部血流减少引起。但是，到目前为止，尚无有效的药物治疗选择。在这里，我们报道了低剂量的苯磺酸左旋氨氯地平可以逆转右单侧颈总动脉闭塞（rUCCAO）的VaD小鼠模型中的认知障碍。与媒介物组相比，口服苯磺酸左旋氨氯地平（0.1 mg / kg）可以减少在MWM测试中发现隐藏平台的潜伏期。此外，经媒介物处理的小鼠发现海马中的磷酸化CaMKII（Thr286）水平降低，可以通过苯磺酸左旋氨氯地平（0.1 mg / kg和0.5 mg / kg）的治疗部分恢复。苯磺酸左旋氨氯地平治疗后未观察到小胶质细胞和星形胶质细胞的显着结果。
更新日期：2019-12-03
中文翻译：
小剂量苯磺酸左旋氨氯地平治疗血管性痴呆的效果。
血管性痴呆（VaD）是一种复杂的疾病，由脑部血流减少引起。但是，到目前为止，尚无有效的药物治疗选择。在这里，我们报道了低剂量的苯磺酸左旋氨氯地平可以逆转右单侧颈总动脉闭塞（rUCCAO）的VaD小鼠模型中的认知障碍。与媒介物组相比，口服苯磺酸左旋氨氯地平（0.1 mg / kg）可以减少在MWM测试中发现隐藏平台的潜伏期。此外，经媒介物处理的小鼠发现海马中的磷酸化CaMKII（Thr286）水平降低，可以通过苯磺酸左旋氨氯地平（0.1 mg / kg和0.5 mg / kg）的治疗部分恢复。苯磺酸左旋氨氯地平治疗后未观察到小胶质细胞和星形胶质细胞的显着结果。
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