暴露于线虫秀丽隐杆线虫的微塑料（1和5μm）会影响其寿命和肠道功能。,Science of the Total Environment

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暴露于线虫秀丽隐杆线虫的微塑料（1和5μm）会影响其寿命和肠道功能。
Science of the Total Environment ( IF 8.2 ) Pub Date : 2019-11-30 , DOI: 10.1016/j.scitotenv.2019.135837
Xu Shang ₁ , Jiawei Lu ₂ , Cheng Feng ₂ , Yimeng Ying ₂ , Yuanchen He ₂ , Sheng Fang ₂ , Ying Lin ₂ , Randy Dahlgren ₃ , Jingjuan Ju ₁

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作为一种新兴的环境污染物，微塑料（MPs）日益被视为陆地和水生生态系统的一个严重健康问题。但是，以前的关于淡水和陆地生物的MP的毒理学研究结果相矛盾，这可能是由于很少进行与环境有关的浓度的研究。在这里，线虫秀丽隐杆线虫（C. elegans）是一种具有水生和陆地自由生活形式的模型生物，用于研究1和5μmMP（107-1010颗粒/ m2）对摄入量，寿命的影响。，排便节律，与排便有关的神经元以及相关基因（skn-1，mkk-4，pmk-1，cpr-1和itr-1）的转录表达。我们证明了MP污染的线虫的百分比随着暴露浓度和持续时间的增加而增加。在暴露72小时后，低浓度暴露组（2.4×107和2.4×108颗粒/ m2）的线虫的寿命下降比高浓度暴露组（2.4×109和2.4×1010颗粒/ m2）的线虫的寿命更显着。同时，在较低的MP浓度下，参与排毒和寿命调节的skn-1基因的表达发生了显着变化。在生理上，暴露72小时后的排便节律受1μmMPs的影响最大，速率为2.4×108颗粒/ m2。1μmMPs对相关基因的显着上调似乎是造成排便间隔缩短的原因。这项研究的结果确定了对C的潜在毒性威胁。线虫在与环境有关的浓度下暴露于MPs中，并为MP对淡水和陆生生物的风险提供了新的证据。胶囊。暴露于1和5μmMPs（107-1010颗粒/ m2）后，秀丽隐杆线虫的寿命在较低浓度下更快地下降。

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Microplastic (1 and 5 μm) exposure disturbs lifespan and intestine function in the nematode Caenorhabditis elegans.

As an emerging environmental pollutant, microplastics (MPs) are increasingly viewed as a serious health concern to terrestrial and aquatic ecosystems. However, previous toxicological studies examining MPs on freshwater and terrestrial organisms provide contradictory results, possibly due to few investigations at environmentally relevant concentrations. Here, the nematode Caenorhabditis elegans (C. elegans), a model organisms with both aquatic and terrestrial free-living forms, was employed to investigate the effects of 1 and 5 μm MPs (107-1010 particles/m2) on the intake, lifespan, defecation rhythm, defecation-related neurons and transcriptional expression of related genes (skn-1, mkk-4, pmk-1, cpr-1 and itr-1). We demonstrated that the percentage of MP-contaminated nematodes increased with increasing exposure concentrations and duration. The lifespan of nematodes in the lower concentration exposure groups (2.4 × 107 and 2.4 × 108 particles/m2) decreased more prominently than that of higher concentration groups (2.4 × 109 and 2.4 × 1010 particles/m2) after a 72-h exposure period. Concomitantly, expression of the skn-1 gene, involved in detoxification and lifespan regulation, was significantly altered at lower MP concentrations. Physiologically, the defecation rhythm after a 72-h exposure period was most strongly affected by 1 μm MPs at 2.4 × 108 particles/m2. The significant up-regulation of related genes by 1 μm MPs appears responsible for the shortened defecation interval. Results of this study identified a potential toxicity threat to C. elegans from exposure to MPs at environmentally relevant concentrations and provide novel evidence for MP risks to freshwater and terrestrial organisms. Capsule. After exposure to 1 and 5 μm MPs (107-1010 particles/m2), the lifespan of C. elegans decreased more rapidly at lower concentrations.

更新日期：2019-11-30

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