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Apigenin Reverses Interleukin-1β-Induced Suppression of Adipocyte Browning via COX2/PGE2 Signaling Pathway in Human Adipocytes.
Molecular Nutrition & Food Research ( IF 4.5 ) Pub Date : 2019-12-09 , DOI: 10.1002/mnfr.201900925
Meshail Okla 1 , Jamal Omran Al Madani 2 , Soonkyu Chung 3 , Musaad Alfayez 4, 5
Affiliation  

Inflammatory responses to obesity, including interleukin‐1 beta (IL‐1β) activation, downregulate mitochondrial function and interfere with adipocyte browning, an important component of energy expenditure. This study investigates the impact of apigenin (Apg), a natural flavonoid with anti‐inflammatory properties, on adipocyte browning in the presence of IL‐1β.

中文翻译:

芹菜素通过人脂肪细胞中的COX2 / PGE2信号通路逆转白介素1β诱导的脂肪细胞褐变的抑制。

对肥胖的炎症反应,包括白介素-1β(IL-1β)激活,下调线粒体功能并干扰脂肪细胞褐变,这是能量消耗的重要组成部分。这项研究调查了芹菜素(Apg),一种具有抗炎特性的天然类黄酮,在IL-1β存在下对脂肪细胞褐变的影响。
更新日期:2019-12-09
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