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Draft genome assembly and transcriptome data of the icefish Chionodraco myersi reveal the key role of mitochondria for a life without hemoglobin at subzero temperatures.
Communications Biology ( IF 5.2 ) Pub Date : 2019-11-29 , DOI: 10.1038/s42003-019-0685-y
Luca Bargelloni 1, 2, 3 , Massimiliano Babbucci 1 , Serena Ferraresso 1 , Chiara Papetti 3, 4 , Nicola Vitulo 5 , Roberta Carraro 1 , Marianna Pauletto 1 , Gianfranco Santovito 3 , Magnus Lucassen 6 , Felix Christopher Mark 6 , Lorenzo Zane 2, 3 , Tomaso Patarnello 1, 3
Affiliation  

Antarctic fish belonging to Notothenioidei represent an extraordinary example of radiation in the cold. In addition to the absence of hemoglobin, icefish show a number of other striking peculiarities including large-diameter blood vessels, high vascular densities, mitochondria-rich muscle cells, and unusual mitochondrial architecture. In order to investigate the bases of icefish adaptation to the extreme Southern Ocean conditions we sequenced the complete genome of the icefish Chionodraco myersi. Comparative analyses of the icefish genome with those of other teleost species, including two additional white-blooded and five red-blooded notothenioids, provided a new perspective on the evolutionary loss of globin genes. Muscle transcriptome comparative analyses against red-blooded notothenioids as well as temperate fish revealed the peculiar regulation of genes involved in mitochondrial function in icefish. Gene duplication and promoter sequence divergence were identified as genome-wide patterns that likely contributed to the broad transcriptional program underlying the unique features of icefish mitochondria.

中文翻译:


冰鱼 Chionodraco myersi 的基因组组装草案和转录组数据揭示了线粒体在零下温度下没有血红蛋白的生命中的关键作用。



属于Notothenioidei的南极鱼是寒冷辐射的一个非凡例子。除了缺乏血红蛋白之外,冰鱼还表现出许多其他显着的特征,包括大直径血管、高血管密度、富含线粒体的肌肉细胞和不寻常的线粒体结构。为了研究冰鱼适应南大洋极端条件的基础,我们对冰鱼 Chionodraco myersi 的完整基因组进行了测序。对冰鱼基因组与其他硬骨鱼物种(包括另外两种白血和五种红血notothenioids)的基因组进行比较分析,为珠蛋白基因的进化丧失提供了新的视角。与红血诺鱼和温带鱼类的肌肉转录组比较分析揭示了冰鱼线粒体功能相关基因的特殊调节。基因重复和启动子序列差异被确定为全基因组模式,可能有助于形成冰鱼线粒体独特特征的广泛转录程序。
更新日期:2019-11-30
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