Roles of aminoacyl-tRNA synthetases in immune regulation and immune diseases.,Cell Death & Disease

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Roles of aminoacyl-tRNA synthetases in immune regulation and immune diseases.
Cell Death & Disease ( IF 8.1 ) Pub Date : 2019-11-28 , DOI: 10.1038/s41419-019-2145-5
Anzheng Nie ₁ , Bao Sun _{2,

3} , Zhihui Fu ₁ , Dongsheng Yu ₁

Affiliation

Aminoacyl-tRNA synthetases (ARSs) play a vital role in protein synthesis by linking amino acids to their cognate transfer RNAs (tRNAs). This typical function has been well recognized over the past few decades. However, accumulating evidence reveals that ARSs are involved in a wide range of physiological and pathological processes apart from translation. Strikingly, certain ARSs are closely related to different types of immune responses. In this review, we address the infection and immune responses induced by pathogen ARSs, as well as the potential anti-infective compounds that target pathogen ARSs. Meanwhile, we describe the functional mechanisms of ARSs in the development of immune cells. In addition, we focus on the roles of ARSs in certain immune diseases, such as autoimmune diseases, infectious diseases, and tumor immunity. Although our knowledge of ARSs in the immunological context is still in its infancy, research in this field may provide new ideas for the treatment of immune-related diseases.

中文翻译：

氨酰基-tRNA合成在免疫调节和免疫疾病中的作用。

氨酰基-tRNA合成酶（ARS）通过将氨基酸与它们的同源转移RNA（tRNA）连接起来，在蛋白质合成中起着至关重要的作用。在过去的几十年中，这种典型的功能已得到公认。但是，越来越多的证据表明，ARS不仅涉及翻译，还涉及广泛的生理和病理过程。令人惊讶的是，某些ARS与不同类型的免疫反应密切相关。在这篇综述中，我们研究了由病原体ARS引起的感染和免疫反应，以及针对病原体ARS的潜在抗感染化合物。同时，我们描述了ARS在免疫细胞发育中的功能机制。此外，我们重点研究ARS在某些免疫性疾病中的作用，例如自身免疫性疾病，传染性疾病和肿瘤免疫。

更新日期：2019-11-29

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