Disulfide-reducing agents play a crucial role in bioconjugate chemistry. Herein, we describe the synthesis of a new disulfide-reducing agent [2-(dibenzylamino)butane-1,4-dithiol (DABDT)] that is conveniently prepared from inexpensive aspartic acid. Being nonmalodorous and highly soluble in a broad range of solvents, DABDT is user-friendly. We have demonstrated its performance both in solution and in the solid phase.

中文翻译：

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2-（二苄基氨基）丁烷-1,4-二硫醇（DABDT），与多种溶剂兼容的友好型二硫化物还原剂。

减少二硫化物的试剂在生物共轭化学中起着至关重要的作用。在这里，我们描述了一种新型的二硫化物还原剂[2-（二苄基氨基）丁烷-1,4-二硫醇（DABDT）]的合成，该合成物可从廉价的天冬氨酸中方便地制备。DABDT无臭且在多种溶剂中高度溶解，因此易于使用。我们已经证明了它在溶液和固相中的性能。