<br>小鼠大脑中的选择、行动和参与的分布式编码,Nature

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小鼠大脑中的选择、行动和参与的分布式编码
Nature ( IF 50.5 ) Pub Date : 2019-11-27 , DOI: 10.1038/s41586-019-1787-x
Nicholas A Steinmetz _{1,

2} , Peter Zatka-Haas ₃ , Matteo Carandini ₁ , Kenneth D Harris ₃

Affiliation

视觉、选择、行动和行为参与源于可能分布在大脑区域的神经元活动。在这里，我们描绘了这些过程背后的神经元的空间分布。我们使用 Neuropixels 探针 1,2 记录了执行视觉辨别任务的小鼠 42 个大脑区域的大约 30,000 个神经元3。当小鼠发起动作时，几乎所有区域的神经元都会做出非特异性反应。相比之下，编码视觉刺激和即将做出的选择的神经元占据了新皮质、基底神经节和中脑的限制区域。选择信号很少见，而且各个地区出现的时间也难以区分。中脑神经元在对侧选择之前被激活，在同侧选择之前被抑制，而前脑神经元可能更喜欢任何一侧。全脑刺激前活动预测了个体试验和整体任务的参与度，参与过程中皮质下活动增强，但新皮质活动受到抑制。这些结果揭示了编码行为相关变量的神经元在小鼠大脑中分布的组织原则。来自 42 个大脑区域的 30,000 个神经元的记录用于描绘小鼠视觉、选择、行动和行为参与背后的神经元活动的空间分布。

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Distributed coding of choice, action and engagement across the mouse brain

Vision, choice, action and behavioural engagement arise from neuronal activity that may be distributed across brain regions. Here we delineate the spatial distribution of neurons underlying these processes. We used Neuropixels probes1,2 to record from approximately 30,000 neurons in 42 brain regions of mice performing a visual discrimination task3. Neurons in nearly all regions responded non-specifically when the mouse initiated an action. By contrast, neurons encoding visual stimuli and upcoming choices occupied restricted regions in the neocortex, basal ganglia and midbrain. Choice signals were rare and emerged with indistinguishable timing across regions. Midbrain neurons were activated before contralateral choices and were suppressed before ipsilateral choices, whereas forebrain neurons could prefer either side. Brain-wide pre-stimulus activity predicted engagement in individual trials and in the overall task, with enhanced subcortical but suppressed neocortical activity during engagement. These results reveal organizing principles for the distribution of neurons encoding behaviourally relevant variables across the mouse brain.Recordings from 30,000 neurons in 42 brain regions are used to delineate the spatial distribution of neuronal activity underlying vision, choice, action and behavioural engagement in mice.

更新日期：2019-11-27

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