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Polysaccharide-Based Lotus Seedpod Surface-Like Porous Microsphere with Precise and Controllable Micromorphology for Ultrarapid Hemostasis.
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2019-12-05 , DOI: 10.1021/acsami.9b17543
Guanghui Xi 1, 2 , Wen Liu 1, 2 , Miao Chen 1 , Qian Li 3 , Xiao Hao 4 , Mingshan Wang 5 , Xiao Yang 6 , Yakai Feng 6 , Hongchao He 7 , Changcan Shi 1, 2 , Wenzhong Li 8
Affiliation  

Rapid water absorption rate has become a bottleneck that limits ultrarapid hemostatic performance of hemostatic microspheres. Herein, we reported a "lotus seedpod surface-like" polysaccharide hemostatic microsphere (PHM) with "macropits on surface" morphology and "micropores in macropits" structure. Unique macropits on surface can promote the water absorption rate because they are advantageous to quickly guide blood into the micropores. Special micropores are internally connected with each other, which endows PHM4 with high water absorption ratio. During the process of blood entering the micropores from micropits, the pore size decreases gradually. In this way, blood clotting factors could be rapidly concentrated. PHM4 showed the highest water absorption rate (40.7 mL/s/cm2) and rapid hemostatic property in vivo (hemostatic time shortened from 210 to 45 s). Lotus seedpod surface-like PHMs are believed to have further clinical application as an effective hemostasis.

中文翻译:

基于多糖的莲子荚表面多孔微球,具有精确且可控的微形态,可用于超快速止血。

快速的吸水率已成为限制止血微球超快速止血性能的瓶颈。在本文中,我们报道了一种具有“表面上的斑点”形态和“大孔中的微孔”结构的“莲花种子表面状”多糖止血微球(PHM)。表面上独特的大坑可以提高吸水率,因为它们有利于快速将血液引导到微孔中。特殊的微孔内部相互连接,使PHM4具有高吸水率。在血液从微坑进入微孔的过程中,孔径逐渐减小。这样,凝血因子可以迅速集中。PHM4表现出最高的吸水率(40。7毫升/秒/平方厘米)和体内快速止血的特性(止血时间从210缩短至45 s)。莲子荚表面状PHM被认为具有进一步的临床应用作为有效的止血作用。
更新日期:2019-12-05
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