Dynamic-Reversible Photoacoustic Probe for Continuous Ratiometric Sensing and Imaging of Redox Status in Vivo,Journal of the American Chemical Society

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Dynamic-Reversible Photoacoustic Probe for Continuous Ratiometric Sensing and Imaging of Redox Status in Vivo
Journal of the American Chemical Society ( IF 14.4 ) Pub Date : 2019-11-26 , DOI: 10.1021/jacs.9b10353
Judun Zheng ₁ , Qin Zeng ₁ , Ruijing Zhang ₁ , Da Xing ₁ , Tao Zhang ₁

Affiliation

Here, we report a reversible photoacoustic (PA) probe BDP-DOH to image the localized redox state in vivo via monitoring the dynamic changes of the redox couple, superoxide anion (O2•-) and glutathione (GSH). The probe features a significant shift in absorption between 680 and 750 nm during selective oxidization with O2•- and the reductive recovery of GSH, thus showing a reversible responsiveness in photoacoustic intensity ratio (PA750/PA680) to successfully visualize the redox status of the tissue in situ. This redox probe with specific and sensitive photoacoustic response provides a potential technical tool towards understanding pathological formation processes.

中文翻译：

用于体内氧化还原状态的连续比率传感和成像的动态可逆光声探针

在这里，我们报告了一种可逆光声 (PA) 探针 BDP-DOH，通过监测氧化还原对、超氧阴离子 (O2•-) 和谷胱甘肽 (GSH) 的动态变化来对体内局部氧化还原状态进行成像。该探针在 O2•- 选择性氧化和 GSH 的还原恢复过程中吸收在 680 和 750 nm 之间发生显着变化，从而显示出光声强度比 (PA750/PA680) 的可逆响应，从而成功地可视化组织的氧化还原状态原地。这种具有特异性和敏感光声响应的氧化还原探针为理解病理形成过程提供了潜在的技术工具。

更新日期：2019-11-26

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