In the present paper, an efficient approach for the construction of 1,N⁶-ethenoadenines from conveniently prepared N⁶-propargyl-adenines is developed. This reaction merges N-iodosuccinimide radical initiation and aerobic aminooxygenation in dioxane. This mild, 5-exo-dig, and metal-free cascade reaction could be applied to a wide substrate scope to provide 1,N⁶-ethenoadenines in moderate to good yields. The reaction mechanism was proposed and tested using radical inhibitor (butylated hydroxytoluene) and isotopic labelling (¹⁸O₂) experiments.

中文翻译：

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N6-炔丙基-腺嘌呤通过 NIS 介导的自由基级联反应无金属合成 1,N6-乙烯腺嘌呤

在本文中，开发了一种从方便制备的N ⁶ -炔丙基-腺嘌呤构建 1, N ⁶ -亚乙基腺嘌呤的有效方法。该反应合并了N-碘​​代琥珀酰亚胺自由基引发和二恶烷中的需氧氨基氧化。这种温和的5-exo-dig和无金属级联反应可应用于广泛的底物范围，以中等至良好的产率提供 1, N ^{6 -亚乙基腺嘌呤。}使用自由基抑制剂（丁基化羟基甲苯）和同位素标记（¹⁸ O ₂）实验提出并测试了反应机理。