Site-Specific Synthesis of Carbazole Derivatives through Aryl Homocoupling and Amination,Synthesis

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Site-Specific Synthesis of Carbazole Derivatives through Aryl Homocoupling and Amination
Synthesis ( IF 2.2 ) Pub Date : 2019-11-26 , DOI: 10.1055/s-0039-1690759
Jaeyoung Ban ₁ , Minkyung Lim ₁ , Saira Shabbir ₂ , Junghyun Baek ₁ , Hakjune Rhee _{1,

3}

Affiliation

We synthesized various carbazoles from anilines through a three-step process with good overall yields (up to 48%). This process comprises N-acetylation, copper(0)-mediated Ullmann homocoupling, and acid-mediated intramolecular amination. It permits various functional groups on the substrate. Scale-up of the developed three-step synthetic route to carbazoles was also demonstrated.

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