One-Pot Absolute Stereochemical Identification of Alcohols via Guanidinium Sulfate Crystallization,Organic Letters

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One-Pot Absolute Stereochemical Identification of Alcohols via Guanidinium Sulfate Crystallization
Organic Letters ( IF 4.9 ) Pub Date : 2019-11-25 , DOI: 10.1021/acs.orglett.9b03792
Beau R. Brummel ₁ , Kinsey G. Lee ₁ , Colin D. McMillen ₁ , Joseph W. Kolis ₁ , Daniel C. Whitehead ₁

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A novel technique for the absolute stereochemical determination of alcohols has been developed that uses crystallization of guanidinium salts of organosulfates. The simple one-pot, two-step process leverages facile formation of guandinium organosulfate single crystals for the straightforward determination of the absolute stereochemistry of enantiopure alcohols by means of X-ray crystallography. The strong hydrogen bonding network drives the stability of the crystal lattice and allows for a diverse range of organic alcohol substrates to be analyzed.

中文翻译：

通过硫酸胍盐结晶一锅法对醇的绝对立体化学鉴定

已经开发出一种用于醇的绝对立体化学测定的新技术，该技术使用了有机硫酸盐的胍盐的结晶。简单的一锅两步方法利用了有机硫酸胍单晶的简便形成，可通过X射线晶体学方法直接测定对映纯醇的绝对立体化学。强大的氢键网络可驱动晶格的稳定性，并允许分析各种有机醇底物。

更新日期：2019-11-28

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