Selective Transesterification of 2,2,2-Trifluoroethyl Phosphates: Synthesis of Mixed Unsymmetrical Phosphates,Organic Letters

当前位置： X-MOL 学术 › Org. Lett. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Selective Transesterification of 2,2,2-Trifluoroethyl Phosphates: Synthesis of Mixed Unsymmetrical Phosphates
Organic Letters ( IF 4.9 ) Pub Date : 2019-11-25 , DOI: 10.1021/acs.orglett.9b04003
Kouta Tsubaki ₁ , Hirokazu Shimooka ₁ , Mitsuru Kitamura ₁ , Tatsuo Okauchi ₁

Affiliation

A selective transesterification starting with tris(2,2,2-trifluoroethyl) phosphate has been developed. This method involves a three-step substitution for 2,2,2-trifluoroethoxy groups and enables the facile synthesis of mixed unsymmetric phosphate triesters from three different alcohols. The substitution of the trifluoroethoxy group at the phosphorus proceeds selectively in the presence of DBU or lithium alkoxides. This method can be applied for the preparation of phospholipids.

中文翻译：

2,2,2-三氟乙基磷酸盐的选择性酯交换反应：混合不对称磷酸盐的合成

已经开发了以磷酸三（2,2,2-三氟乙基）酯为起始的选择性酯交换反应。该方法涉及三步取代2,2,2-三氟乙氧基，并能够从三种不同的醇轻松合成混合的不对称磷酸三酯。在DBU或烷氧基锂的存在下，磷中三氟乙氧基的取代选择性进行。该方法可用于制备磷脂。

更新日期：2019-11-28

点击分享查看原文

点击收藏

阅读更多本刊新发论文本刊介绍/投稿指南