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mRNA Recruiting eIF4 Factors Involved in Protein Synthesis and Its Regulation.
Biochemistry ( IF 2.9 ) Pub Date : 2019-12-04 , DOI: 10.1021/acs.biochem.9b00788
Rishi Kumar Mishra 1 , Ayushi Datey 1 , Tanweer Hussain 1
Biochemistry ( IF 2.9 ) Pub Date : 2019-12-04 , DOI: 10.1021/acs.biochem.9b00788
Rishi Kumar Mishra 1 , Ayushi Datey 1 , Tanweer Hussain 1
Affiliation
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The recruitment of mRNA onto the ribosome affects not only global translation but also the spatial and temporal fine-tuning of eukaryotic translation initiation. The eukaryotic initiation factor 4 (eIF4) factors, namely, eIF4G, eIF4E, eIF4A, and eIF4B, facilitate the recruitment of mRNA onto the preassembled 43S pre-initiation complex (PIC), thus leading to the formation of the 48S PIC. Several biochemical and genetic studies have established the roles of eIF4 factors; however, the available structural information is limited. While structures of some of the individual components and subcomplexes are available, the structural details of activated mRNA bound to eIF4 factors (eIF4-mRNA) are missing. Structural characterization of the eIF4-mRNA in association with the 43S PIC in different organisms is crucial for a detailed understanding of mRNA recruitment and for exploiting the structural differences for possible drug design.
中文翻译：
参与蛋白质合成及其调控的eIF4因子的mRNA募集。
mRNA募集到核糖体上不仅影响整体翻译，而且影响真核翻译起始的时空微调。真核起始因子4（eIF4）因子，即eIF4G，eIF4E，eIF4A和eIF4B，有助于将mRNA募集到预先组装的43S预起始复合物（PIC）上，从而导致形成48S PIC。几项生化和遗传研究已经确定了eIF4因子的作用。但是，可用的结构信息是有限的。虽然某些单个成分和亚复合物的结构可用，但缺少与eIF4因子（eIF4-mRNA）结合的活化mRNA的结构细节。
更新日期：2019-12-04
中文翻译：
参与蛋白质合成及其调控的eIF4因子的mRNA募集。
mRNA募集到核糖体上不仅影响整体翻译，而且影响真核翻译起始的时空微调。真核起始因子4（eIF4）因子，即eIF4G，eIF4E，eIF4A和eIF4B，有助于将mRNA募集到预先组装的43S预起始复合物（PIC）上，从而导致形成48S PIC。几项生化和遗传研究已经确定了eIF4因子的作用。但是，可用的结构信息是有限的。虽然某些单个成分和亚复合物的结构可用，但缺少与eIF4因子（eIF4-mRNA）结合的活化mRNA的结构细节。
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