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Effect of (−)-Epicatechin on Poorly Crystalline and Amorphous Precipitate. The Role of Green Tea Compound in the Formation of Infectious Urinary Stones
Crystal Growth & Design ( IF 3.2 ) Pub Date : 2019-12-09 , DOI: 10.1021/acs.cgd.9b00936 Jolanta Prywer 1 , Ewa Mielniczek-Brzóska 2
Crystal Growth & Design ( IF 3.2 ) Pub Date : 2019-12-09 , DOI: 10.1021/acs.cgd.9b00936 Jolanta Prywer 1 , Ewa Mielniczek-Brzóska 2
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Infectious urinary stones induced to grow by urease-producing bacteria consist of aggregates of bacteria, highly crystalline struvite, and poorly crystalline and amorphous precipitate (PCaAP). The paper describes an experimental study on the influence of (−)-epicatechin, a green tea component, on the nucleation and growth of PCaAP. The crystallization process of PCaAP was performed in artificial urine, and the activity of bacteria was simulated by the addition of aqueous ammonia solution. The formation of struvite was avoided by using Mg-free artificial urine. Optical microscopy methods and spectrophotometric measurements both confirm that (−)-epicatechin promotes the nucleation and growth of PCaAP. This means that PCaAP nucleation is shifted toward a lower pH compared to the control test. The results of the experiments are explained based on the theoretical analysis of the chemical species formed in artificial urine. This chemical speciation analysis shows that the experimentally observed effects are due to the effect of (−)-epicatechin on the formation of CaCO3, CaHPO4, CaC2O4, CaCit–, and HPO42– species.
中文翻译：
（-）-表儿茶素对不良结晶和非晶态沉淀物的影响。绿茶化合物在感染性尿结石形成中的作用
由产生脲酶的细菌诱导生长的传染性泌尿系结石由细菌，高结晶性鸟粪石以及不良结晶和无定形沉淀物（PCaAP）的聚集体组成。这篇论文描述了关于绿茶成分（-）-表儿茶素对PCaAP成核和生长的影响的实验研究。在人造尿液中进行PCaAP的结晶过程，并通过添加氨水模拟细菌的活性。通过使用不含镁的人造尿液避免了鸟粪石的形成。光学显微镜法和分光光度法测量都证实（-）-表儿茶素能促进PCaAP的成核和生长。这意味着与对照测试相比，PCaAP成核向较低的pH方向移动。基于对人造尿中形成的化学物种的理论分析，解释了实验结果。该化学形态分析表明，实验观察到的作用是由于（-）-表儿茶素对CaCO形成的作用所致3，CaHPO 4，CaC 2 O 4，CaCit –和HPO 4 2 –种类。
更新日期：2019-12-09
中文翻译：
（-）-表儿茶素对不良结晶和非晶态沉淀物的影响。绿茶化合物在感染性尿结石形成中的作用
由产生脲酶的细菌诱导生长的传染性泌尿系结石由细菌，高结晶性鸟粪石以及不良结晶和无定形沉淀物（PCaAP）的聚集体组成。这篇论文描述了关于绿茶成分（-）-表儿茶素对PCaAP成核和生长的影响的实验研究。在人造尿液中进行PCaAP的结晶过程，并通过添加氨水模拟细菌的活性。通过使用不含镁的人造尿液避免了鸟粪石的形成。光学显微镜法和分光光度法测量都证实（-）-表儿茶素能促进PCaAP的成核和生长。这意味着与对照测试相比，PCaAP成核向较低的pH方向移动。基于对人造尿中形成的化学物种的理论分析，解释了实验结果。该化学形态分析表明，实验观察到的作用是由于（-）-表儿茶素对CaCO形成的作用所致3，CaHPO 4，CaC 2 O 4，CaCit –和HPO 4 2 –种类。
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