A series of trifluoromethyl pyridine derivatives containing an 1,3,4‐oxadiazole moiety was synthesized and characterized by ¹H NMR, ¹⁹F NMR, ¹³C NMR, and HR‐MS. The bio‐assay results indicated that some of the synthesized compounds exhibited good insecticidal activity against Mythimna separate and Plutella xylostella. Most of the synthesized compound showed 100% activity against the two pests at 500 mg⋅L⁻¹; in practically, the value of median lethal concentration (LC₅₀) for some title compounds was much lower than that of commercial chlorpyrifos. Preliminary structure‐activity relationship was also discussed.

中文翻译：

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带有1,3,4-恶二唑部分的新型三氟甲基吡啶衍生物作为潜在的杀虫剂

合成了一系列包含1,3,4-恶二唑部分的三氟甲基吡啶衍生物，并通过¹ H NMR，¹⁹ F NMR，¹³ C NMR和HR-MS进行了表征。生物测定结果表明，某些合成的化合物对Mythimna分离株和小菜蛾具有良好的杀虫活性。在500 mg·L ^-1时，大多数合成化合物对两种害虫均表现出100％的活性。实际上，某些标题化合物的致死浓度中值（LC ₅₀）远低于商业毒死that。初步的构效关系也进行了讨论。