Heligmosomoides polygyrus bakeri感染了小肠蠕虫，不断改变着整个小鼠小肠和大肠中的微生物群落。,International Journal for Parasitology

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Heligmosomoides polygyrus bakeri感染了小肠蠕虫，不断改变着整个小鼠小肠和大肠中的微生物群落。
International Journal for Parasitology ( IF 3.7 ) Pub Date : 2019-11-22 , DOI: 10.1016/j.ijpara.2019.09.005
Alexis Rapin ₁ , Audrey Chuat ₁ , Luc Lebon ₁ , Mario M Zaiss ₁ , Benjamin J Marsland ₂ , Nicola L Harris ₁

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越来越多的证据表明，肠道蠕虫感染可以改变肠道微生物群落，对哺乳动物宿主产生重要影响。但是，迄今为止，所有研究均使用不同的技术来研究微生物组并进入肠道的不同部位，各研究之间几乎没有一致性。在本研究中，我们着手对肠道蠕虫感染对哺乳动物肠道细菌微生物组的影响进行全面分析。为此，我们调查了使用天然鼠科小肠蠕虫Heligmosomoides polygyrus bakeri实验感染的影响，并检查了整个小肠和大肠黏膜和腔内细菌群落的可能变化。我们还探讨了寄生虫批次和感染前微生物组等常见实验变量对蠕虫-细菌相互作用的影响。这项工作提供了证据，证明蠕虫感染可重现地改变肠道微生物群落，并在肠道的整个长度上引起感染的影响。尽管蠕虫引起的肠道微生物组改变的确切性质因感染前存在的微生物群落结构而异，但改变的范围远远超出了感染幼虫引入新细菌种类的范围。此外，还注意到了不同实验之间的惊人相似之处，包括整个肠道内一致的肽链球菌科细菌的生长。

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Infection with a small intestinal helminth, Heligmosomoides polygyrus bakeri, consistently alters microbial communities throughout the murine small and large intestine.

Increasing evidence suggests that intestinal helminth infection can alter intestinal microbial communities with important impacts on the mammalian host. However, all of the studies to date utilize different techniques to study the microbiome and access different sites of the intestine with little consistency noted between studies. In the present study, we set out to perform a comprehensive analysis of the impact of intestinal helminth infection on the mammalian intestinal bacterial microbiome. For this purpose, we investigated the impact of experimental infection using the natural murine small intestinal helminth, Heligmosomoides polygyrus bakeri and examined possible alterations in both the mucous and luminal bacterial communities along the entire small and large intestine. We also explored the impact of common experimental variables including the parasite batch and pre-infection microbiome, on the outcome of helminth-bacterial interactions. This work provides evidence that helminth infection reproducibly alters intestinal microbial communities, with an impact of infection noted along the entire length of the intestine. Although the exact nature of helminth-induced alterations to the intestinal microbiome differed depending on the microbiome community structure present prior to infection, changes extended well beyond the introduction of new bacterial species by the infecting larvae. Moreover, striking similarities between different experiments were noted, including the consistent outgrowth of a bacterium belonging to the Peptostreptococcaceae family throughout the intestine.

更新日期：2019-11-22

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