Stereoselective benzylic amination reaction is important for their further application as pharmaceuticals and agrochemicals, and other chemical entities. Herein, we describe the diastereoselective amination of 1,2-anti-dialkoxychromane on chromane framework using chlorosulfonyl isocyanate. Notably, the utility of this protocol is highlighted by the total synthesis of chromanol 293B and cromakalim.

中文翻译：

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通过手性苯甲醚的立体选择性胺化法合成铬醇293B和克罗卡林

立体选择性苄基胺化反应对于将其进一步用作药物和农用化学品以及其他化学实体很重要。在这里，我们描述了使用氯磺酰基异氰酸酯在苯甲醚骨架上1,2-抗二烷氧基苯并二氢吡喃的非对映选择性胺化。值得注意的是，该方法的实用性通过苯并二氢吡喃酚293B和克罗马卡林的全合成来突出。