Pyrido[2,3-d]pyrimidines (1) are a type of privileged heterocyclic scaffolds capable of providing ligands for several receptors in the body. Among such structures, our group and others have been particularly interested in pyrido[2,3-d]pyrimidine-7(8H)-ones (2) due to the similitude with nitrogen bases present in DNA and RNA. Currently there are more than 20,000 structures 2 described which correspond to around 2900 references (half of them being patents). Furthermore, the number of references containing compounds of general structure 2 have increased almost exponentially in the last 10 years. The present review covers the synthetic methods used for the synthesis of pyrido[2,3-d]pyrimidine-7(8H)-ones (2), both starting from a preformed pyrimidine ring or a pyridine ring, and the biomedical applications of such compounds.

中文翻译：

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Pyrido[2,3-d]pyrimidin-7(8H)-ones：合成和生物医学应用

吡啶并 [2,3-d] 嘧啶 (1) 是一种特殊的杂环支架，能够为体内多种受体提供配体。在这些结构中，由于与 DNA 和 RNA 中存在的氮碱基相似，我们的小组和其他人对吡啶并 [2,3-d] 嘧啶-7(8H)-ones (2) 特别感兴趣。目前，描述了超过 20,000 个结构 2，它们对应于大约 2900 个参考文献（其中一半是专利）。此外，在过去 10 年中，包含通式结构 2 化合物的参考文献数量几乎呈指数增长。本综述涵盖了从预先形成的嘧啶环或吡啶环开始合成吡啶并[2,3-d]嘧啶-7(8H)-酮 (2) 的合成方法，以及这种合成方法的生物医学应用。化合物。