Antifungal Macrocyclic Trichothecenes from the Insect-Associated Fungus Myrothecium roridum.,Journal of Agricultural and Food Chemistry

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Antifungal Macrocyclic Trichothecenes from the Insect-Associated Fungus Myrothecium roridum.
Journal of Agricultural and Food Chemistry ( IF 5.7 ) Pub Date : 2019-11-15 , DOI: 10.1021/acs.jafc.9b04507
Tian-Xiao Li ₁ , Ya-Mei Xiong ₁ , Xin Chen ₁ , Ya-Nan Yang ₁ , Ying Wang ₁ , Xue-Wei Jia ₁ , Xue-Peng Yang ₁ , Lan-Lan Tan ₂ , Chun-Ping Xu ₁

Affiliation

Three new macrocyclic trichothecenes possessing rare 6'-ketal moieties, roridoxins A-C (1-3), and five known compounds (4-8) were isolated from the insect-associated fungus Myrothecium roridum. Their structures were confirmed by a combination of NMR and HRESIMS data, while their absolute configurations were unambiguously determined by single-crystal X-ray analysis and electronic circular dichroism experiments. Trichothecenes 1 and 3 showed potent antifungal activities against four strains of phytopathogenic fungi. In addition, 1, 3, 5, and 6 were found to significantly inhibit the cell growth of Candida albicans with minimal inhibitory concentration values from 8.8 to 18.5 μg/mL. Moreover, they were able to inhibit the biofilm formation of C. albicans better than the positive control.

中文翻译：

来自与昆虫相关的真菌Myrothecium roridum的抗真菌大环孢霉烯。

从昆虫相关的真菌Myrothecium roridum中分离了三个具有罕见的6'-缩酮部分的新的大环曲霉菌，roridoxins AC（1-3）和五个已知的化合物（4-8）。通过NMR和HRESIMS数据的组合证实了它们的结构，而通过单晶X射线分析和电子圆二色性实验明确地确定了它们的绝对构型。Trichothecenes 1和3表现出对四种菌株的植物致病真菌的有效抗真菌活性。此外，发现1、3、5和6可显着抑制白色念珠菌的细胞生长，其最低抑制浓度值为8.8至18.5μg/ mL。而且，与阳性对照相比，它们能够更好地抑制白色念珠菌的生物膜形成。

更新日期：2019-11-17

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